Relation of Acute Decompensated Heart Failure to Silent Cerebral Infarcts in Patients With Reduced Left Ventricular Ejection Fraction

Heart failure (HF) is a prothrombotic state with increased rate of thromboembolic events. Magnetic resonance imaging studies demonstrated increased rate of silent cerebral infarcts (SCI) in this patient group and SCIs were shown lead to dementia, cognitive decline, and depression. We aimed to show a...

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Bibliographic Details
Published in:The American journal of cardiology 2019-06, Vol.123 (11), p.1835-1839
Main Authors: Ozyuncu, Nil, Gulec, Sadi, Kaya, Cansin Tulunay, Goksuluk, Huseyin, Tan, Turkan Seda, Vurgun, Veysel Kutay, Us, Ebru, Erol, Cetin
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Aged
Aged, 80 and over
Aneurysms
Anticoagulants
Biomarkers
Cardiac arrhythmia
Cardiology
Cerebral Infarction - etiology
Cognitive ability
Compensation
Congestive heart failure
Dementia disorders
Ejection fraction
Female
Fibrillation
Heart
Heart failure
Heart Failure - etiology
Hospitalization
Humans
Ischemia
Magnetic resonance imaging
Male
Mental depression
Middle Aged
NMR
Nuclear magnetic resonance
Phosphopyruvate hydratase
Pulmonary arteries
Smoking
Stroke
Stroke Volume
Thromboembolism
Ventricle
Ventricles (cerebral)
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - physiopathology
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Summary:Heart failure (HF) is a prothrombotic state with increased rate of thromboembolic events. Magnetic resonance imaging studies demonstrated increased rate of silent cerebral infarcts (SCI) in this patient group and SCIs were shown lead to dementia, cognitive decline, and depression. We aimed to show acute decompensated phase is associated with increased rate of recent SCI in reduced ejection fraction HF patients. HF patients with sinus rhythm hospitalized for acute decompensation were studied. Neuron specific enolase (NSE), a sensitive neuronal ischemia marker, was used to detect recent SCI. Decompensated and compensated phase blood samples for NSE were collected on the day of admission and on the third day of compensation, respectively. One hundred and forty seven patients with mean age of 72 were studied. There were significantly more patients with positive NSE levels at decompensated state (29% vs 4%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2019.02.055