Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

• Published in: Clinical immunology (Orlando, Fla.) Fla.), 2019-06, Vol.203, p.1-8
• Main Authors: Watad, Abdulla, Bragazzi, Nicola Luigi, McGonagle, Dennis, Adawi, Mohammed, Bridgewood, Charlie, Damiani, Giovanni, Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Quaresma, Mariana, Amital, Howard, Shoenfeld, Yehuda
• Format: Article
• Language: English
• Subjects: Adjuvants, Immunologic; Adolescent; Adult; Aged; Aged, 80 and over; ASIA syndrome; Autoimmune Diseases - epidemiology; Child; Child, Preschool; Connective Tissue Diseases - epidemiology; Female; Foreign material; Giant Cell Arteritis - epidemiology; Hepatitis B Vaccines - immunology; Humans; Infant; Infant, Newborn; Inflammation - epidemiology; Influenza Vaccines - immunology; International syndrome registry; Israel - epidemiology; Male; Middle Aged; Silicone breast implants; Syndrome; Vaccination - statistics & numerical data; Vaccines; Young Adult
• ISSN: 1521-6616; 1521-7035
• DOI: 10.1016/j.clim.2019.03.007

We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p