Effect of curcumin-nanoemulsion associated with photodynamic therapy in breast adenocarcinoma cell line

[Display omitted] Curcumin, a natural compound has several antineoplastic activities and is a promising natural photosensitizer used in photodynamic therapy. However, its low solubility in physiological medium limit the clinical use of curcumin. This study aimed to analyze the action of curcumin-nan...

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Published in:Bioorganic & medicinal chemistry 2019-05, Vol.27 (9), p.1882-1890
Main Authors: Machado, Francielly Cristina, Adum de Matos, Renata Prandini, Primo, Fernando Lucas, Tedesco, Antonio Claudio, Rahal, Paula, Calmon, Marília Freitas
Format: Article
Language:English
Subjects:
Apoptosis - drug effects
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Caspase 3 - metabolism
Caspase 7
Cell Proliferation - drug effects
Curcumin
Curcumin - chemistry
Curcumin - pharmacology
Curcumin - therapeutic use
Female
Humans
Light
MCF-7 Cells
Nanostructures - chemistry
Nanotechnology
Particle Size
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Reactive Oxygen Species - metabolism
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Summary:[Display omitted] Curcumin, a natural compound has several antineoplastic activities and is a promising natural photosensitizer used in photodynamic therapy. However, its low solubility in physiological medium limit the clinical use of curcumin. This study aimed to analyze the action of curcumin-nanoemulsion, a new and well-designed Drug Delivery System (DDS+) molecule, used as a photosensitizing agent in photodynamic therapy in an in vitro breast cancer model, MCF-7 cells. The empty nanoemulsion fulfils all necessary requirements to be an excellent DDS. Furthermore, the use of curcumin-nanoemulsion in photodynamic therapy resulted in a high phototoxic effect after activation at 440 nm, decreasing to
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2019.03.044