Rhein Inhibits the Migration of Ovarian Cancer Cells through Down-Regulation of Matrix Metalloproteinases

The root of Rheum officinale BAILL as a traditional Chinese medicine, which main function is removing heat from the blood, promoting blood circulation and clearing toxins away. Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is one of the most important active components in the root of Rheum of...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2019/04/01, Vol.42(4), pp.568-572
Main Authors: Ren, Baoyin, Guo, Weijia, Tang, Yawei, Zhang, Jing, Xiao, Nan, Zhang, Lin, Li, Weiling
Format: Article
Language:English
Subjects:
Anthraquinones - pharmacology
anti-migration effect
Antineoplastic Agents - pharmacology
Assaying
Blood circulation
Carboxylic acids
Cell adhesion & migration
Cell Line, Tumor
Cell migration
Cell Movement - drug effects
Cell proliferation
Down-Regulation - drug effects
Female
Herbal medicine
Humans
Matrix metalloproteinase
Matrix Metalloproteinases - metabolism
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - metabolism
Rhein
Rheum officinale
Traditional Chinese medicine
Tumor cell lines
Tumor cells
Tumors
Wound healing
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Summary:The root of Rheum officinale BAILL as a traditional Chinese medicine, which main function is removing heat from the blood, promoting blood circulation and clearing toxins away. Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is one of the most important active components in the root of Rheum officinale BAILL, which could inhibit the proliferation of tumor cells. However, the study on the mechanism of anti-cell migration capacity of Rhein on ovarian cancer is not yet clear. Here, we demonstrated that Rhein had dose-dependent effects of ovarian tumors on drugs and could inhibit the proliferations and migration of two typical ovarian cancer cell lines, A2780 and OV2008. Furthermore, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays showed that the survival rate of ovarian cancer cells was significantly decreased when treated with Rhein. Rhein inhibited the proliferation of ovarian cancer cells in dose-dependent manner. Moreover, the wound healing assay and transwell assay indicated that the cell migratory potential and expression of matrix metalloproteinases were markedly inhibited by Rhein. Our findings suggested that Rhein could be a potential candidate to be developed as a drug for the prevention of ovarian cancer cell migration.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-00431