Toxicity and clinical outcomes of partial breast irradiation compared to whole breast irradiation for early-stage breast cancer: a systematic review and meta-analysis

Purpose There is uncertainty about outcomes differences between partial breast irradiation (PBI) and whole breast irradiation (WBI) for early-stage breast cancer. Methods Prospective randomized trials comparing adjuvant PBI to WBI in early-stage invasive breast cancer were identified using PubMed. O...

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Bibliographic Details
Published in:Breast cancer research and treatment 2019-06, Vol.175 (3), p.531-545
Main Authors: Korzets, Yasmin, Fyles, Anthony, Shepshelovich, Daniel, Amir, Eitan, Goldvaser, Hadar
Format: Article
Language:English
Subjects:
Brachytherapy
Breast cancer
Cancer research
Clinical trials
Death
Invasiveness
Mastectomy
Medicine
Medicine & Public Health
Meta-analysis
Oncology
Patients
Radiation
Radiation therapy
Review
Statistics
Systematic review
Toxicity
Tumors
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Summary:Purpose There is uncertainty about outcomes differences between partial breast irradiation (PBI) and whole breast irradiation (WBI) for early-stage breast cancer. Methods Prospective randomized trials comparing adjuvant PBI to WBI in early-stage invasive breast cancer were identified using PubMed. Odds ratios (OR), 95% confidence intervals and absolute risks were computed for pre-specified efficacy and toxicity outcomes including cosmesis. Subgroup analysis evaluated the effect of PBI modality (external beam radiation treatment [EBRT], intraoperative radiation treatment [IORT] or brachytherapy) on efficacy. Meta-regression analysis explored the influence of median follow-up, patient and tumor characteristics on results. Results Nine trials comprising 14514 patients were included. While PBI was associated with increased odds of local recurrence compared to WBI (OR 1.69, P  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-019-05209-9