Miniaturized optical fiber tweezers for cell separation by optical force

In advanced biomedicine and microfluidics, there is a strong desire to sort and manipulate various cells and bacteria based on miniaturized microfluidic chips. Here, by integrating fiber tweezers into a T-type microfluidic channel, we report an optofluidic chip to selectively trap Escherichia coli i...

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Bibliographic Details
Published in:Optics letters 2019-04, Vol.44 (7), p.1868-1871
Main Authors: Liu, Shaojing, Li, Zongbao, Weng, Zhe, Li, Yuqi, Shui, Lingling, Jiao, Zhongxing, Chen, Yilin, Luo, Aiping, Xing, Xiaobo, He, Sailing
Format: Article
Language:English
Subjects:
Animals
Bacteria
Cell Separation - instrumentation
Controllability
E coli
Equipment Design
Erythrocytes - microbiology
Escherichia coli - cytology
Finite difference method
Humans
Microfluidics
Miniaturization - instrumentation
Optical Fibers
Optical Tweezers
Separation
Water quality
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Summary:In advanced biomedicine and microfluidics, there is a strong desire to sort and manipulate various cells and bacteria based on miniaturized microfluidic chips. Here, by integrating fiber tweezers into a T-type microfluidic channel, we report an optofluidic chip to selectively trap Escherichia coli in human blood solution based on different sizes and shapes. Furthermore, we simulate the trapping and pushing regions of other cells and bacteria, including rod-shaped bacteria, sphere-shaped bacteria, and cancer cells based on finite-difference analysis. With the advantages of controllability, low optical power, and compact construction, the strategy may be possibly applied in the fields of optical separation, cell transportation, and water quality analysis.
ISSN:0146-9592
1539-4794
DOI:10.1364/OL.44.001868