Black chokeberry (Aronia melanocarpa) polyphenols reveal different antioxidant, antimicrobial and neutrophil-modulating activities

•Quercetin and epicatechin are the strongest antioxidants in black chokeberry.•Proanthocyanidins contribute mostly to black chokeberry antioxidant activity.•Black chokeberry polyphenols have mild effect on PMA-activated CL of neutrophils.•Black chokeberry polyphenols have profound effect on OZP-acti...

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Bibliographic Details
Published in:Food chemistry 2019-06, Vol.284, p.108-117
Main Authors: Denev, Petko, Číž, Milan, Kratchanova, Maria, Blazheva, Denica
Format: Article
Language:English
Subjects:
Anthocyanins
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antimicrobial properties
Antioxidant activity
Antioxidants - chemistry
Antioxidants - pharmacology
Black chokeberry (Aronia melanocarpa) fruits
Catechin
Chlorogenic Acid
Fruit - chemistry
Galactosides
Humans
Neutrophils
Neutrophils - drug effects
Oxidative burst
Phenols
Photinia - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Polyphenols
Polyphenols - chemistry
Polyphenols - pharmacology
Proanthocyanidins
Quercetin
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Summary:•Quercetin and epicatechin are the strongest antioxidants in black chokeberry.•Proanthocyanidins contribute mostly to black chokeberry antioxidant activity.•Black chokeberry polyphenols have mild effect on PMA-activated CL of neutrophils.•Black chokeberry polyphenols have profound effect on OZP-activated CL of neutrophils.•Black chokeberry proanthocyanidins are the strongest antimicrobial agents in the fruit. The current study reports data on antioxidant, antimicrobial and neutrophil-modulating activities of different polyphenolic preparations from black chokeberry fruits: crude extract, purified extract standardized to 20% and 40% anthocyanins, and proanthocyanidins; as well as pure compounds (chlorogenic acid, cyanidin-3-O-galactoside, epicatechin, rutin and quercetin) present in black chokeberries. Minor phenolic components - quercetin and epicatechin showed the highest ORAC and TRAP antioxidant activity. Given the amount of individual phenolics in the fruits, proanthocyanidins are the major contributor to antioxidant activity of fresh black chokeberries. Studied polyphenols and preparations had no effect on the spontaneous chemiluminescence (CL) of human neutrophils and only mild effect on PMA-activated CL. Greater effects were observed on OZP-activated CL, being statistically significant (p 
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2019.01.108