Assessment of chemically characterized Salvia sclarea L. essential oil and its combination with linalyl acetate as novel plant based antifungal, antiaflatoxigenic and antioxidant agent against herbal drugs contamination and probable mode of action

The present investigation reports antifungal and antiaflatoxigenic efficacy of essential oil (SSEO) and its combination with Linalyl acetate (LA) (1:1) against herbal drug deteriorating molds and aflatoxin B contamination. GC-MS analysis of SSEO showed Linalyl Acetate (LA) (61.33%) and Linalool (LL)...

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Bibliographic Details
Published in:Natural product research 2021-03, Vol.35 (5), p.782-787
Main Authors: Kumar Singh, Vipin, Das, Somenath, Kumar Dwivedy, Abhishek, Kumar Chaudhari, Anand, Upadhyay, Neha, Dubey, Nawal Kishore
Format: Article
Language:English
Subjects:
Acetic acid
Aflatoxin B1
Aflatoxins
Aflatoxins - analysis
Antifungal Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Aquatic plants
Contamination
Drug Contamination
Ergosterol
Essential oils
Free Radical Scavengers - pharmacology
Fungi - drug effects
Fungicides
Herbal medicine
Linalool
Linalyl acetate
Mode of action
Monoterpenes - pharmacology
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Pharmaceutical Preparations
Pyruvaldehyde
Reduction
Rhizomes
Salvia - chemistry
Salvia sclarea
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Summary:The present investigation reports antifungal and antiaflatoxigenic efficacy of essential oil (SSEO) and its combination with Linalyl acetate (LA) (1:1) against herbal drug deteriorating molds and aflatoxin B contamination. GC-MS analysis of SSEO showed Linalyl Acetate (LA) (61.33%) and Linalool (LL) (17.59%) as major components. The SSEO and LA combination displayed better antifungal and antiaflatoxigenic activity as compared to SSEO and LA used individually. SSEO and LA combination was effective in reduction of ergosterol and enhanced leakage of vital ions and UV-absorbing materials in a dose dependent manner. The combination caused significant reduction in cellular methylglyoxal content, an aflatoxin inducer suggesting its future application for development of aflatoxin resistant herbal drug varieties through green transgenics. The combination also showed pronounced antioxidant activity as compared to SSEO and LA used separately. Interestingly, the combination showed significant protection of rhizomes against mould infestation.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1593168