Ficus extract—A promising agent for antimammary tumorigenesis: A review on current status and future possibilities

Pharmacological studies have shown that various species of Ficus have antiviral, antidiarrheal, antipyretic, hypolipidemic, antidiabetic, antioxidant, anticancer, antiparasitic, antiangiogenic, anti‐inflammatory, antibacterial, antiplatelet, reproductive, dermatological, immunological, endocrine, an...

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Bibliographic Details
Published in:Phytotherapy research 2019-06, Vol.33 (6), p.1597-1603
Main Authors: Remadevi, Viji, Mohan Lathika, Lakshmi, Sasikumar Sujatha, Anjana, Sreeharshan, Sreeja
Format: Article
Language:English
Subjects:
Animals
Antiangiogenics
Antidiabetics
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Bioavailability
Biomolecules
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Carcinogenesis - drug effects
chemo sensitizer
Data mining
Diabetes mellitus
Drug Resistance, Neoplasm - drug effects
Drug Synergism
Female
Ficus - chemistry
Ficus religiosa
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Immunology
Inflammation
Leaves
Pharmacology
Photosensitization
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
photosensitizing effect
Plant extracts
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Reactive oxygen species
Tumorigenesis
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Summary:Pharmacological studies have shown that various species of Ficus have antiviral, antidiarrheal, antipyretic, hypolipidemic, antidiabetic, antioxidant, anticancer, antiparasitic, antiangiogenic, anti‐inflammatory, antibacterial, antiplatelet, reproductive, dermatological, immunological, endocrine, and hepato and nephron protective effects. But there is no sufficient research on biomolecules present in the leaf extract of Ficus religiosa and its mechanism of action. We have previously reported that bioavailable constituents of F. religiosa leaf extract exert photosensitizing and apoptosis‐inducing capability through the generation of intracellular reactive oxygen species on breast cancer cells. In this review, we have evaluated the expression of checkpoint proteins of G1/S and sub G0 phase with wet lab data and also have done a data mining of other research for other potential mechanistic action of the F. religiosa leaf extract.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6348