Association of statin use with Parkinson's disease: Dose–response relationship

Background There have been conflicting results on the association between statin use and Parkinson's disease (PD) incidence. Objectives This study investigated the association between time‐varying status of statin use and incidence of PD while considering the dose–response relationship and tota...

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Bibliographic Details
Published in:Movement disorders 2019-07, Vol.34 (7), p.1014-1021
Main Authors: Jeong, Su‐Min, Jang, Wooyoung, Shin, Dong Wook
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cholesterol
Cohort Studies
Databases, Factual
Dementia - drug therapy
Dementia - etiology
Dementia disorders
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Incidence
Male
Middle Aged
Movement disorders
National Health Programs - statistics & numerical data
Neurodegenerative diseases
Parkinson Disease - complications
Parkinson Disease - drug therapy
Parkinson's disease
Proportional Hazards Models
Risk Factors
Statin
Statins
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Summary:Background There have been conflicting results on the association between statin use and Parkinson's disease (PD) incidence. Objectives This study investigated the association between time‐varying status of statin use and incidence of PD while considering the dose–response relationship and total cholesterol level. Methods Using the database of the Korean National Health Insurance Service from 2002 to 2015, we examined 76,043 subjects (≥60 years old) free of PD, dementia, and stroke at baseline. The dose of statin use was classified into the following four 6‐month categories (
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.27681