High expression of Anxa2 and Stat3 promote progression of hepatocellular carcinoma and predict poor prognosis

• Published in: Pathology, research and practice research and practice, 2019-06, Vol.215 (6), p.152386-152386, Article 152386
• Main Authors: Tang, Lei, Liu, Jin-Xia, Zhang, Zi-Juan, Xu, Chen-Zhou, Zhang, Xue-Ning, Huang, Wei-Rong, Zhou, Dan-Hua, Wang, Rong-Rong, Chen, Xu-Dong, Xiao, Ming-Bing, Qu, Li-Shuai, Lu, Cui-Hua
• Format: Article
• Language: English
• Subjects: Adult; Aged; Annexin A2 - biosynthesis; Anxa2; Biomarkers, Tumor - analysis; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Disease Progression; Female; Hepatocellular carcinoma; Humans; Kaplan-Meier Estimate; Liver Neoplasms - metabolism; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Male; Middle Aged; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Prognosis; Recurrence; Stat3; STAT3 Transcription Factor - biosynthesis; Survival
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2019.03.015

To elucidate whether the interaction between Anxa2 and Stat3 could promote the progression of hepatocellular carcinoma (HCC) and that high co-expression of Anxa2 and Stat3 could predict poor prognosis in HCC patients. We investigated Anxa2 and Stat3 expression using Western blot analysis in 4 HCC and adjacent nontumor tissues and using immunohistochemistry in 100 patients’ paraffin sections. Then we assessed the expression of Stat3, Anxa2 and co-expression of Stat3 and Anxa2 with relevant clinical pathological parameters and their prognostic value in HCC patients. The recurrence and overall survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models. The incidence of high Stat3 expression in HCC tissues (35%) was significantly higher than that in non-HCC tissues (8%) (P