Dosimetric predictors for postoperative pulmonary complications in esophageal cancer following neoadjuvant chemoradiotherapy and surgery

•Postoperative pulmonary complications occurred in 22.1% following neoadjuvant chemoradiotherapy and surgery for esophageal cancer.•Pre-radiotherapy FEV1 and mean lung dose were the most relevant risk factors for postoperative pulmonary complications.•Mean lung dose having 20% risk of pulmonary comp...

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Bibliographic Details
Published in:Radiotherapy and oncology 2019-04, Vol.133, p.87-92
Main Authors: Cho, Won Kyung, Oh, Dongryul, Kim, Hong Kwan, Ahn, Yong Chan, Noh, Jae Myoung, Shim, Young Mog, Zo, Jae Ill, Choi, Yong Soo, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Myung-Ju, Park, Keunchil, Nam, Heerim
Format: Article
Language:English
Subjects:
Adult
Aged
Chemoradiotherapy, Adjuvant - adverse effects
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Female
Humans
Lung - diagnostic imaging
Lung - radiation effects
Lung Diseases - diagnostic imaging
Lung Diseases - etiology
Male
Middle Aged
Neoadjuvant chemoradiotherapy
Neoadjuvant Therapy - adverse effects
Postoperative complication
Postoperative Complications - etiology
Postoperative Period
Predictive Value of Tests
Pulmonary complication
Radiation Injuries - diagnostic imaging
Radiation Injuries - etiology
Radiometry
Retrospective Studies
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Summary:•Postoperative pulmonary complications occurred in 22.1% following neoadjuvant chemoradiotherapy and surgery for esophageal cancer.•Pre-radiotherapy FEV1 and mean lung dose were the most relevant risk factors for postoperative pulmonary complications.•Mean lung dose having 20% risk of pulmonary complications was 9.4 Gy and 7 Gy for those with FEV1 ≥ 2L and FEV1 
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2019.01.005