Systemic lupus erythematosus is a risk factor for atrial fibrillation: a nationwide, population-based study

Cardiac involvement is present in more than half of the patients with systemic lupus erythematosus (SLE). However, large-scale studies on the prevalence of atrial fibrillation (AF) in this disease do not exist. We aimed to investigate the incidence and clinical significance of AF in SLE. Patients wi...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2019-11, Vol.37 (6), p.1019-1025
Main Authors: Lim, Sang Yup, Bae, Eun Hui, Han, Kyung-Do, Jung, Jin-Hyung, Choi, Hong Sang, Kim, Chang Seong, Ma, Seong Kwon, Kim, Soo Wan
Format: Article
Language:English
Subjects:
Adult
Atrial Fibrillation - epidemiology
Atrial Fibrillation - etiology
Cohort Studies
Female
Humans
Incidence
Lupus Erythematosus, Systemic - complications
Male
Middle Aged
Retrospective Studies
Risk Factors
Taiwan
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Summary:Cardiac involvement is present in more than half of the patients with systemic lupus erythematosus (SLE). However, large-scale studies on the prevalence of atrial fibrillation (AF) in this disease do not exist. We aimed to investigate the incidence and clinical significance of AF in SLE. Patients with SLE (n=21,143; mean age, 41.8±13.13 years; female, 90.38%) without previous AF were selected from the Korean National Health Insurance Service National Sample Cohort database between 2008 and 2014. Age-and sex-matched controls (n=105,715) were randomly sampled in a 5:1 ratio from the population of individuals without SLE from the same database. Both cohorts were followed-up for incidental AF and death until 2015. AF was newly detected in 481 (2.27%) patients with SLE and 619 (0.59%) controls (incidence: 3.692 and 0.941 per 1000 person-years, respectively). After multivariate adjustment, SLE was found to be a risk factor for developing AF [hazard ratio (HR), 2.84; 95% confidence interval (CI), 2.50-3.23]. On subgroup analysis, younger (age
ISSN:0392-856X