Volumetric abdominal perfusion measurement using a pseudo‐randomly sampled 3D fast‐spin‐echo (FSE) arterial spin labeling (ASL) sequence and compressed sensing reconstruction

• Published in: Magnetic resonance in medicine 2019-08, Vol.82 (2), p.680-692
• Main Authors: Taso, Manuel, Zhao, Li, Guidon, Arnaud, Litwiller, Daniel V., Alsop, David C.
• Format: Article
• Language: English
• Subjects: Abdomen; Abdomen - diagnostic imaging; acceleration; Adult; arterial spin labeling; Breathing; compressed sensing; Density; High acceleration; Humans; Image processing; Image Processing, Computer-Assisted - methods; Image quality; Image reconstruction; Kidney - diagnostic imaging; kidneys; Labeling; Magnetic Resonance Imaging - methods; Oversampling; pCASL; Perfusion; Perfusion Imaging - methods; Phantoms, Imaging; Quality; Random sampling; Respiration; Sampling; Spin labeling; Spin Labels; Subtraction; Variation; Young Adult
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.27761

Purpose To improve image quality and spatial coverage for abdominal perfusion imaging by implementing an arterial spin labeling (ASL) sequence that combines variable‐density 3D fast‐spin‐echo (FSE) with Cartesian trajectory and compressed‐sensing (CS) reconstruction. Methods A volumetric FSE sequence was modified to include background‐suppressed pseudo‐continuous ASL labeling and to support variable‐density (VD) Poisson‐disk sampling for acceleration. We additionally explored the benefits of center oversampling and variable outer k‐space sampling. Fourteen healthy volunteers were scanned on a 3T scanner to test acceleration factors as well as the various sampling schemes described under synchronized‐breathing to limit motion issues. A CS reconstruction was implemented using the BART toolbox to reconstruct perfusion‐weighted ASL volumes, assessing the impact of acceleration, different reconstruction, and sampling strategies on image quality. Results CS acceleration is feasible with ASL, and a strong renal perfusion signal could be observed even at very high acceleration rates (≈15). We have shown that ASL k‐space complex subtraction was desirable before CS reconstruction. Although averaging of multiple highly accelerated images helped to reduce artifacts from physiologic fluctuations, superior image quality was achieved by interleaving of different highly undersampled pseudo‐random spatial sampling patterns and using 4D‐CS reconstruction. Combination of these enhancements produces high‐quality ASL volumes in under 5 min. Conclusions High‐quality isotropic ASL abdominal perfusion volumes can be obtained in healthy volunteers with a VD‐FSE and CS reconstruction. This lays the groundwork for future developments toward whole abdomen free‐breathing non‐contrast perfusion imaging.