Pilot study: placental biomarker predictive capability (sFlt-1, PlGF and their ratio) of postpartum maternal outcome

Background Prenatal measurement of placental biomarkers was able to improve screening and diagnosis of preeclampsia. Little is known about the clinical role of placental biomarkers in the postpartum period. Methods This study is a prospective monocentric trial that included a total of 30 women with...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2019-06, Vol.299 (6), p.1557-1566
Main Authors: Hamza, Amr, Gerlinger, Ch, Radosa, J., Solomayer, E. F., Hagmann, J., Sester, U., Bohle, R., Stroeder, R., Takacs, Z., Meyberg-Solomayer, G., Juhasz-Boess, I., Kasoha, M.
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers - blood
Blood pressure
Cohort Studies
Endocrinology
Female
Gynecology
Human Genetics
Humans
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Postpartum Period
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
Prospective Studies
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Summary:Background Prenatal measurement of placental biomarkers was able to improve screening and diagnosis of preeclampsia. Little is known about the clinical role of placental biomarkers in the postpartum period. Methods This study is a prospective monocentric trial that included a total of 30 women with preeclamptic pregnancies. Serum placental biomarkers including soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) were measured before and 2 h after delivery by Enzyme-Linked Immunosorbent Assay (ELISA) using commercially available kits according to manufacturer’s instructions and correlated with the postpartum outcome. Results Postpartum higher serum PlGF level was associated with postpartum elevation of the systolic blood pressure. Yet, the placental biomarkers were not able to predict general worsening of postpartum preeclampsia or other individual clinical or laboratory parameters. Conclusion Serum concentrations of sFlt-1 and PlGF or their ratio in our study cohort did not completely predict the occurrence of postpartum preeclampsia. Yet, postpartum higher serum PlGF level was associated with postpartum elevation of the systolic blood pressure.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-019-05128-6