Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice

Apolipoprotein E (APOE) deficient mice exhibit unexplained hypercorticosteronemia. Given that APOE is also produced locally within the adrenals, we evaluated the effect of adrenal-specific APOE deficiency on the glucocorticoid function. Hereto, one adrenal containing or lacking APOE was transplanted...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2019-06, Vol.490, p.21-27
Main Authors: van der Sluis, Ronald J., Depuydt, Marie A.C., Verwilligen, Robin A.F., Hoekstra, Menno, Van Eck, Miranda
Format: Article
Language:English
Subjects:
Adrenal
Adrenal Cortex - drug effects
Adrenal Cortex - metabolism
Adrenal transplantation
Animals
Apolipoprotein E
Apolipoproteins E - biosynthesis
Apolipoproteins E - deficiency
Cholesterol - metabolism
Endoplasmic Reticulum Stress - drug effects
Glucocorticoid
Glucocorticoids - pharmacology
Mice, Inbred C57BL
Mice, Knockout
Organ Specificity
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Apolipoprotein E (APOE) deficient mice exhibit unexplained hypercorticosteronemia. Given that APOE is also produced locally within the adrenals, we evaluated the effect of adrenal-specific APOE deficiency on the glucocorticoid function. Hereto, one adrenal containing or lacking APOE was transplanted into adrenalectomized wild-type mice. Adrenal APOE deficiency did not impact adrenal total cholesterol levels. Importantly, the ability of the two adrenal types to produce glucocorticoids was also not different as judged from the similar plasma corticosterone levels. Adrenal mRNA expression levels of HMG-CoA reductase and the LDL receptor were decreased by respectively 72% (p 
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2019.04.001