Does Autophagy Promote Longevity? It Depends

Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals. Zhou et a...

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Bibliographic Details
Published in:Cell 2019-04, Vol.177 (2), p.221-222
Main Authors: Savini, Marzia, Wang, Meng C.
Format: Article
Language:English
Subjects:
Animals
Autophagy
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Longevity
Permeability
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Summary:Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals. Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2019.03.021