Early childhood adversity associations with nightmare severity and sleep spindles

• Published in: Sleep medicine 2019-04, Vol.56, p.57-65
• Main Authors: Nielsen, Tore, Carr, Michelle, Picard-Deland, Claudia, Marquis, Louis-Philippe, Saint-Onge, Kadia, Blanchette-Carrière, Cloé, Paquette, Tyna
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adverse childhood experience; Adverse Childhood Experiences - statistics & numerical data; Brain Waves - physiology; Comorbidity; Dreams - physiology; Female; Humans; Middle Aged; Nightmares; Parasomnias; Parasomnias - epidemiology; Post-traumatic stress disorder; Psychological Trauma - epidemiology; Severity of Illness Index; Sleep; Sleep Stages - physiology; Stress Disorders, Post-Traumatic - epidemiology; Stress-acceleration theory; Young Adult
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2019.03.004

Childhood adversity figures prominently in the clinical histories of children and adolescents suffering from a panoply of physical, mental or sleep disorders, including posttraumatic stress disorder. But the nature and prevalence of early adversity in the case of idiopathic nightmare-prone individuals have received little study. We characterize the types and frequencies of self-reported childhood adversity for nightmare-prone individuals using the developmentally sensitive Traumatic Antecedents Questionnaire (TAQ) and assess relationships between separation adversity and sleep spindles. The TAQ was administered to 73 non-treatment-seeking volunteers with frequent idiopathic nightmares and 67 healthy controls. Nightmare severity, anxiety, depression, alexithymia and past and present sleep disorders were also assessed. Sleep was recorded with polysomnography (PSG) for 90 participants and sleep spindles were assessed for 63. Nightmare-prone participants scored higher on most TAQ measures, including adversity at 0–6 years of age. TAQ-derived scales assessing traumatic and nontraumatic forms of adversity were both elevated for nightmare-prone participants; for 0–6 year estimates, nontraumatic adversity was associated with nightmares independent of trauma adversity. Group differences were only partially mediated by current psychopathology symptoms and were largely independent of nightmare frequency but not of nightmare distress. Adversity/nightmare relationships were graded differentially for the two study groups. Separation adversity at 0–6 years of age correlated with current sleep spindle anomalies—in particular, lower slow spindle density—an anomaly known to index both psychopathology and early nightmare-onset. Self-reported adversity occurring as young as 0–6 years of age is associated with nightmare severity and sleep spindle anomalies. Adversity-linked nightmares may reflect pathophysiological mechanisms common also to the nightmares of pre-clinical and full-blown post-traumatic stress disorder. •Nightmare-prone individuals report higher 0–6 year adversity scores than do controls.•Self-reported separation at 0–6 years is correlated with current sleep spindle features.•Preschool adversity may lead to both nightmares and sleep spindle changes.•Adversity-related changes may result from a mechanism similar to how trauma produces the nightmares of post-traumatic stress disorder.