Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography

Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on...

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Bibliographic Details
Published in:Anticancer research 2019-04, Vol.39 (4), p.1667-1673
Main Authors: Gkantaifi, Areti, Papadopoulos, Christodoulos, Spyropoulou, Despoina, Toumpourleka, Maria, Iliadis, George, Kardamakis, Dimitrios, Nikolaou, Michail, Tsoukalas, Nikolaos, Kyrgias, George, Tolia, Maria
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - blood
Breast cancer
Breast Neoplasms - radiotherapy
Cardiotoxicity
Congestive heart failure
Coronary artery disease
Echocardiography
Echocardiography - methods
Female
Heart
Heart - physiopathology
Heart - radiation effects
Heart Diseases - blood
Heart Diseases - diagnostic imaging
Heart Diseases - etiology
Heart Diseases - physiopathology
Humans
Morbidity
Predictive Value of Tests
Radiation
Radiation effects
Radiation Injuries - blood
Radiation Injuries - diagnostic imaging
Radiation Injuries - etiology
Radiation Injuries - physiopathology
Radiation therapy
Radiotherapy - adverse effects
Risk Factors
Serum levels
Toxicity
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Summary:Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on the detection of early cardiac dysfunction. Several studies that reported changes in either echocardiographic and/or serum levels measurements after breast radiotherapy were searched. Despite the established role of cardiac biomarkers to predict late cardiotoxicity after radiotherapy, data concerning early cardiac damage are still lacking. Furthermore, although strain echocardiography represents a specific tool for the detection of cardiac morbidity in certain diseases, much interest concerns its role in the prediction of early heart failure after radiotherapy. Identification of new tools for the detection of early cardiotoxicity after breast radiotherapy may minimize the side-effects of therapeutic modalities in the clinical setting.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13272