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Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography
Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on...
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| Published in: | Anticancer research 2019-04, Vol.39 (4), p.1667-1673 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 1673 |
| container_issue | 4 |
| container_start_page | 1667 |
| container_title | Anticancer research |
| container_volume | 39 |
| creator | Gkantaifi, Areti Papadopoulos, Christodoulos Spyropoulou, Despoina Toumpourleka, Maria Iliadis, George Kardamakis, Dimitrios Nikolaou, Michail Tsoukalas, Nikolaos Kyrgias, George Tolia, Maria |
| description | Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on the detection of early cardiac dysfunction. Several studies that reported changes in either echocardiographic and/or serum levels measurements after breast radiotherapy were searched. Despite the established role of cardiac biomarkers to predict late cardiotoxicity after radiotherapy, data concerning early cardiac damage are still lacking. Furthermore, although strain echocardiography represents a specific tool for the detection of cardiac morbidity in certain diseases, much interest concerns its role in the prediction of early heart failure after radiotherapy. Identification of new tools for the detection of early cardiotoxicity after breast radiotherapy may minimize the side-effects of therapeutic modalities in the clinical setting. |
| doi_str_mv | 10.21873/anticanres.13272 |
| format | article |
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Several studies that reported changes in either echocardiographic and/or serum levels measurements after breast radiotherapy were searched. Despite the established role of cardiac biomarkers to predict late cardiotoxicity after radiotherapy, data concerning early cardiac damage are still lacking. Furthermore, although strain echocardiography represents a specific tool for the detection of cardiac morbidity in certain diseases, much interest concerns its role in the prediction of early heart failure after radiotherapy. Identification of new tools for the detection of early cardiotoxicity after breast radiotherapy may minimize the side-effects of therapeutic modalities in the clinical setting.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.13272</identifier><identifier>PMID: 30952705</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Animals ; Biomarkers ; Biomarkers - blood ; Breast cancer ; Breast Neoplasms - radiotherapy ; Cardiotoxicity ; Congestive heart failure ; Coronary artery disease ; Echocardiography ; Echocardiography - methods ; Female ; Heart ; Heart - physiopathology ; Heart - radiation effects ; Heart Diseases - blood ; Heart Diseases - diagnostic imaging ; Heart Diseases - etiology ; Heart Diseases - physiopathology ; Humans ; Morbidity ; Predictive Value of Tests ; Radiation ; Radiation effects ; Radiation Injuries - blood ; Radiation Injuries - diagnostic imaging ; Radiation Injuries - etiology ; Radiation Injuries - physiopathology ; Radiation therapy ; Radiotherapy - adverse effects ; Risk Factors ; Serum levels ; Toxicity</subject><ispartof>Anticancer research, 2019-04, Vol.39 (4), p.1667-1673</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Apr 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-469145ec6a6667a39e2095bf2d66b8c436c2c4c7899ea8ce645c279ec6f384983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30952705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gkantaifi, Areti</creatorcontrib><creatorcontrib>Papadopoulos, Christodoulos</creatorcontrib><creatorcontrib>Spyropoulou, Despoina</creatorcontrib><creatorcontrib>Toumpourleka, Maria</creatorcontrib><creatorcontrib>Iliadis, George</creatorcontrib><creatorcontrib>Kardamakis, Dimitrios</creatorcontrib><creatorcontrib>Nikolaou, Michail</creatorcontrib><creatorcontrib>Tsoukalas, Nikolaos</creatorcontrib><creatorcontrib>Kyrgias, George</creatorcontrib><creatorcontrib>Tolia, Maria</creatorcontrib><title>Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on the detection of early cardiac dysfunction. Several studies that reported changes in either echocardiographic and/or serum levels measurements after breast radiotherapy were searched. Despite the established role of cardiac biomarkers to predict late cardiotoxicity after radiotherapy, data concerning early cardiac damage are still lacking. Furthermore, although strain echocardiography represents a specific tool for the detection of cardiac morbidity in certain diseases, much interest concerns its role in the prediction of early heart failure after radiotherapy. Identification of new tools for the detection of early cardiotoxicity after breast radiotherapy may minimize the side-effects of therapeutic modalities in the clinical setting.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cardiotoxicity</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Echocardiography</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Heart</subject><subject>Heart - physiopathology</subject><subject>Heart - radiation effects</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnostic imaging</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - physiopathology</subject><subject>Humans</subject><subject>Morbidity</subject><subject>Predictive Value of Tests</subject><subject>Radiation</subject><subject>Radiation effects</subject><subject>Radiation Injuries - blood</subject><subject>Radiation Injuries - diagnostic imaging</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - physiopathology</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Risk Factors</subject><subject>Serum levels</subject><subject>Toxicity</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkctOwzAQRS0EoqXwAWyQJTZsUhw7tpNlW4WHVAmpLevIdSYkJY2LnSDl7zFtAYmVN-dcz8xF6DokYxrGkt2rpq20aiy4cciopCdoGMokDCRn5BQNCeUkkITwAbpwbkOIEEnMztGAkYRTSfgQmakF5Vq8UHll2hKs2vVYNTlOla17PMk_wTrAM2XzSmmcFgXo1o3xqgS8MDVgU-Al2G6Lp5XZKvvu8b2_bK2qGpzq0uhv2bz56LK_RGeFqh1cHd8Ren1IV7OnYP7y-DybzAPNJG2DSCRhxEELJYSQiiVA_cjrguZCrGMdMaGpjrSMkwRUrEFEXFOZeKFgceSXHKG7Q-7Omo8OXJttK6ehrlUDpnMZpcT_ISTlHr39h25MZxs_nacop4zEknoqPFDaGucsFNnOVn7hPgtJtm8j-2sj27fhnZtjcrfeQv5r_JyffQHRvIeS</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Gkantaifi, Areti</creator><creator>Papadopoulos, Christodoulos</creator><creator>Spyropoulou, Despoina</creator><creator>Toumpourleka, Maria</creator><creator>Iliadis, George</creator><creator>Kardamakis, Dimitrios</creator><creator>Nikolaou, Michail</creator><creator>Tsoukalas, Nikolaos</creator><creator>Kyrgias, George</creator><creator>Tolia, Maria</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201904</creationdate><title>Breast Radiotherapy and Early Adverse Cardiac Effects. 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| ispartof | Anticancer research, 2019-04, Vol.39 (4), p.1667-1673 |
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| source | EZB Electronic Journals Library |
| subjects | Animals Biomarkers Biomarkers - blood Breast cancer Breast Neoplasms - radiotherapy Cardiotoxicity Congestive heart failure Coronary artery disease Echocardiography Echocardiography - methods Female Heart Heart - physiopathology Heart - radiation effects Heart Diseases - blood Heart Diseases - diagnostic imaging Heart Diseases - etiology Heart Diseases - physiopathology Humans Morbidity Predictive Value of Tests Radiation Radiation effects Radiation Injuries - blood Radiation Injuries - diagnostic imaging Radiation Injuries - etiology Radiation Injuries - physiopathology Radiation therapy Radiotherapy - adverse effects Risk Factors Serum levels Toxicity |
| title | Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography |
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