Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review

Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this sys...

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Bibliographic Details
Published in:Anticancer research 2019-04, Vol.39 (4), p.1651-1660
Main Authors: Aurello, Paolo, Berardi, Giammauro, Moschetta, Giovanni, Cinquepalmi, Matteo, Antolino, Laura, Nigri, Giuseppe, D'Angelo, Francesco, Valabrega, Stefano, Ramacciato, Giovanni
Format: Article
Language:English
Subjects:
Aged
Anastomosis, Surgical - adverse effects
Anastomotic Leak - diagnosis
Anastomotic Leak - etiology
Cancer
Carcinoma - pathology
Carcinoma - surgery
Complications
Esophageal cancer
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagectomy - adverse effects
Esophagogastric Junction - pathology
Esophagogastric Junction - surgery
Esophagus
Female
Gastrectomy - adverse effects
Humans
Leakage
Male
Middle Aged
Morbidity
Neoplasm Recurrence, Local
Patients
Risk Assessment
Risk Factors
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgery
Systematic review
Time Factors
Treatment Outcome
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Summary:Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients. The frequency of anastomotic leakage ranged from 7.2 to 11.2%. Patients affected by anastomotic leakage had a recurrence rate of 9-56%. Closer follow-up or even more aggressive oncological therapy should be considered for patients affected by anastomotic leakage after surgery for carcinoma of the distal esophagus and gastroesophageal junction.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13270