Relation Between New York Heart Association Functional Class and Objective Measures of Cardiopulmonary Exercise in Adults With Congenital Heart Disease

• Published in: The American journal of cardiology 2019-06, Vol.123 (11), p.1868-1873
• Main Authors: Das, Bibhuti B., Young, Ming-Lon, Niu, Jianli, Mendoza, Laura E., Chan, Kak-Chen, Roth, Todd
• Format: Article
• Language: English
• Subjects: Adult; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Congenital diseases; Coronary artery disease; Correlation analysis; Exercise Test; Female; Heart Defects, Congenital - classification; Heart Defects, Congenital - physiopathology; Heart diseases; Heart failure; Heart rate; Humans; Male; Oxygen consumption; Oxygen uptake; Patients; Physical training; Retrospective Studies; Ventilation; Young Adult
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2019.02.053

We aimed to compare New York Heart Association (NYHA) functional class in adult congenital heart disease (ACHD) patients with objectively measured cardiopulmonary exercise testing (CPET) parameters. This study included retrospective review of ACHD patients who underwent a CPET between August 2014 and April 2018 at our center. Patients were grouped according to severity of CHD, and NYHA class as recorded in their medical record or estimated from the clinical narrative. A total of 175 ACHD patients (mean age 30 ± 11 years) with NYHA class I-III enrolled in the study. The NYHA functional class was II or III in most complex CHD. There was a strong inverse relation between NYHA class and peak oxygen consumption, oxygen uptake efficiency slope, and the double product at peak exercise (product of heart rate and systolic blood pressure) (p