Frequency of ALK and GD2 Expression in Neuroblastoma

Background: The aim of this study was to elucidate the significance of immunohistochemical staining patterns of ALK and GD2 in peripheral neuroblastic tumors with different stages and favorable/unfavorable features. Materials and methods: 32 neuroblastomas, 7 ganglioneuroblastomas, and 1 ganglioneur...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2019-07, Vol.38 (4), p.326-334
Main Authors: Aygün, Zeynep, Batur, Şebnem, Emre, Şenol, Celkan, Tiraje, Özman, Oktay, Comunoglu, Nil
Format: Article
Language:English
Subjects:
Adolescent
ALK
Anaplastic Lymphoma Kinase - genetics
Anaplastic Lymphoma Kinase - metabolism
Biomarkers, Tumor - metabolism
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Cell Differentiation
Child
Child, Preschool
Female
Ganglioneuroblastoma - genetics
Ganglioneuroblastoma - metabolism
Ganglioneuroma - genetics
Ganglioneuroma - metabolism
Gangliosides - genetics
Gangliosides - metabolism
GD2
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Infant
Infant, Newborn
Male
Neuroblastoma
Neuroblastoma - genetics
Neuroblastoma - metabolism
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Summary:Background: The aim of this study was to elucidate the significance of immunohistochemical staining patterns of ALK and GD2 in peripheral neuroblastic tumors with different stages and favorable/unfavorable features. Materials and methods: 32 neuroblastomas, 7 ganglioneuroblastomas, and 1 ganglioneuroma cases were immunohistochemically stained with ALK and GD2, and the expressions were graded and correlated with differentiation, size, and favorable/unfavorable histology. Results: There was no statistically significant correlation between ALK immunopositivity and tumor differentiation or stage. Although there was no statistically significant correlation between GD2 immunopositivity and stage, the intensity and prevalence of GD2 immunostaining were statistically significantly higher in the well differentiated group and in tumors which were smaller than 10 cm. Conclusion: GD2 immunostaining levels correlated with tumor differentiation and size. ALK immunostaining was not related to tumor differentiation or stage.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2019.1588439