Antifungal Susceptibility Profile of Candida Albicans Isolated from Vulvovaginal Candidiasis in Xinjiang Province of China

• Published in: Mycopathologia (1975) 2019-06, Vol.184 (3), p.413-422
• Main Authors: Yan, Liang, Wang, Xiao-dong, Seyedmousavi, Seyedmojtaba, Yuan, Juan-na, Abulize, Palida, Pan, Wei-hua, Yu, Nong, Yang, Ya-li, Hu, Hai-qing, Liao, Wan-qing, Deng, Shu-wen
• Format: Article
• Language: English
• Subjects: Adult; Antifungal agents; Antifungal Agents - pharmacology; Biomedical and Life Sciences; Candida albicans; Candida albicans - drug effects; Candida albicans - isolation & purification; Candidiasis; Candidiasis, Vulvovaginal; Candidiasis, Vulvovaginal - microbiology; Caspofungin; China; Echinocandins; Eukaryotic Microbiology; Female; Fluconazole; Flucytosine; Fungicides; Humans; Itraconazole; Life Sciences; Medical Microbiology; Micafungin; Microbial Ecology; Microbial Sensitivity Tests; Microbiology; Minimum inhibitory concentration; Original Paper; Plant Sciences; Posaconazole; Ravuconazole; Triazoles; Voriconazole; Young Adult
• ISSN: 0301-486X; 1573-0832
• DOI: 10.1007/s11046-018-0305-2

We investigated the antifungal susceptibility profiles of 207 independent Candida albicans strains isolated from patients with vulvovaginal candidiasis (VVC) in Xinjiang Province of China. Using CLSI M27-A3 and M27-S4 guidelines, anidulafungin and micafungin were the most active drugs against C. albicans showing an MIC 50 /MIC 90 corresponding to 0.016/0.0313 µg/mL, followed by caspofungin (0.25/0.25 µg/mL), posaconazole (0.125/0.5 µg/mL), ravuconazole (0.063/1 µg/mL), itraconazole (0.125/1 µg/mL), amphotericine B (0.5/1 µg/mL), isavuconazole (0.063/2 µg/mL), 5-flucytosine (1/2 µg/mL), voriconazole (0.125/4 µg/mL), and fluconazole (0.5/4 µg/mL). 96.1% (199)–100.0% (207) isolates were sensitive to the three echinocandins tested, amphotericine B and 5-flucytosine. The in vitro activity of triazoles against all isolates tested was variable; itraconazole and voriconazole had reduced the activity to almost half of the isolates (55.1% (114) and 51.2% (106) susceptible, respectively). Fluconazole was active against 76.3% (158) isolates tested. The new triazoles ravuconazole, isavuconazole and posaconazole showed good in vitro potency against 89.9% (186)–95.2% (197) of isolates with the geometric mean MIC (µg/mL) of 0.10, 0.12 and 0.14 µg/mL, respectively. In conclusion, our study indicates that for effective management of systemic candidiasis in Xinjiang Province of China, it is important to determine the susceptibility profiles of isolated C. albicans from patients with VVC.