Plasma lipid profile comparison of five different cancers by nanoflow ultrahigh performance liquid chromatography-tandem mass spectrometry

A comprehensive lipidomic analysis at the molecular level using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was performed to elucidate the lipid profiles of patient blood samples from five commonly found cancers (liver, lun...

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Bibliographic Details
Published in:Analytica chimica acta 2019-07, Vol.1063, p.117-126
Main Authors: Lee, Gwang Bin, Lee, Jong Cheol, Moon, Myeong Hee
Format: Article
Language:English
Subjects:
Abundance
Cancer
Chromatography
Colorectal cancer
Diagnostic systems
Diglycerides
Gastric cancer
Ionization
Ions
Lecithin
Lipidomics
Lipids
Liquid chromatography
Liver
Liver cancer
Lung cancer
Lungs
Lysophosphatidic acid
Mass spectrometry
Mass spectroscopy
Phosphatidylcholine
Phosphatidylethanolamine
Plasma
Scientific imaging
Species
Spectroscopy
Sphingomyelin
Thyroid
Thyroid cancer
Thyroid gland
Triglycerides
UHPLC-ESI-MS/MS
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Summary:A comprehensive lipidomic analysis at the molecular level using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (nUHPLC-ESI-MS/MS) was performed to elucidate the lipid profiles of patient blood samples from five commonly found cancers (liver, lung, gastric, colorectal, and thyroid), which were then compared with the lipid profiles of healthy controls. From a total of 335 lipids identified and quantified, 50 high abundance lipids showing significant changes (>2-fold and p 2-fold change; p 
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2019.02.021