Are breast conservation treatment rates optimized for Asian women with symptomatic malignancies?

• Published in: ANZ journal of surgery 2019-05, Vol.89 (5), p.529-535
• Main Authors: Tan, Mona P. C., Sitoh, Yih Yiow
• Format: Article
• Language: English
• Subjects: Asian population; Breast cancer; breast conservation treatment; Chemotherapy; Health care facilities; mastectomy; Patients; Survival; symptomatic breast cancers; Tumors
• ISSN: 1445-1433; 1445-2197
• DOI: 10.1111/ans.15084

Background Published data indicate that 20–40% of patients undergo breast conservation treatment (BCT) in Asia, which is below an indicative benchmark of 50%. With an increasing body of evidence suggesting that BCT might be associated with improved survival outcomes, it is exigent to increase BCT utilization. This study was therefore undertaken to evaluate BCT rates for women presenting with symptomatic breast cancer and potential for de‐escalation of surgical treatment. Methods All patients who presented with symptomatic tumours and underwent surgical treatment at the authors’ healthcare facility between January 2009 and December 2011 were included in this retrospective study. Standard wide excision was performed to achieve clear margins and reasonable cosmetic outcomes for BCT‐eligible patients. Oncoplastic techniques such as therapeutic mammoplasty or volume replacement with flaps were not employed. Results A total of 116 women presented with symptomatic breast cancer. The majority (92.2%) were Asian. Mean age at diagnosis was 48.3 years and mean tumour size was 23.4 mm. Ninety‐five patients (81.9%) underwent BCT. Of the 22 patients, 13 (59%) who underwent neoadjuvant chemotherapy had sufficient tumour size downstaging to successfully undergo BCT instead of mastectomy. Conclusion It is possible for more than 80% of Asian women with symptomatic breast malignancies to undergo BCT, with the appropriate use of neoadjuvant medical therapy and surgical techniques. As increasing data indicate improved survival with BCT, this should be offered as the treatment of choice. Breast conservation treatment (BCT) rates among Asian women have been reported to be between 20% and 40%, which is significantly below the benchmark of 50%. This study was performed to determine if BCT rates can be further increased in the light of contemporary data which suggest that women receiving BCT have superior overall, breast cancer‐specific and local recurrence‐free survival rates.