Genome-wide analysis of differentially expressed lncRNA in sporadic parathyroid tumors

Summary Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. The “lncRNA...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2019-07, Vol.30 (7), p.1511-1519
Main Authors: Jiang, T., Wei, B. J., Zhang, D. X., Li, L., Qiao, G. L., Yao, X. A., Chen, Z. W., Liu, X., Du, X. Y.
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - complications
Adenoma - diagnosis
Adenoma - genetics
Adult
Aged
Bioinformatics
Biomarkers
Cancer
Carcinoma
Carcinoma - complications
Carcinoma - diagnosis
Carcinoma - genetics
Diagnosis
Diagnosis, Differential
Endocrinology
Female
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Genome-Wide Association Study - methods
Genomes
Humans
Hyperparathyroidism, Primary - etiology
Hyperparathyroidism, Primary - genetics
Male
Medical diagnosis
Medicine
Medicine & Public Health
Middle Aged
Neuroendocrine tumors
Original Article
Orthopedics
Parathyroid
Parathyroid Neoplasms - complications
Parathyroid Neoplasms - diagnosis
Parathyroid Neoplasms - genetics
Polymerase chain reaction
Real-Time Polymerase Chain Reaction - methods
Rheumatology
RNA, Long Noncoding - genetics
RNA, Messenger - genetics
RNA, Neoplasm - genetics
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. The “lncRNA score” calculated from these lncRNAs differentiated parathyroid carcinomas from adenomas. LncRNAs serve as biomarkers for parathyroid cancer diagnosis. Introduction Diagnosis of parathyroid carcinoma (PC) on histological examination is challenging. LncRNA profile study was conducted to find diagnostic biomarkers for PC. Methods LncRNA arrays containing 91,007 lncRNAs as well as 29,857 mRNAs were used to assess parathyroid specimen (5 carcinomas and 6 adenomas). Bioinformatics analyses were also conducted to compare the microarray results between parathyroid carcinomas and adenomas (PAs). Differentially expressed lncRNAs of 11 PCs and 31 PAs were validated by real-time quantitative PCR. Results On the microarray data between PC and PA samples (fold change ≥ 2, P  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-019-04959-y