Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy

• Published in: Journal of pharmacy and pharmacology 2019-05, Vol.71 (5), p.725-732
• Main Authors: Grover, Madhuri, Shah, Karan, Khullar, Gaurav, Gupta, Jyoti, Behl, Tapan
• Format: Article
• Language: English
• Subjects: Curcuma; Diabetes; Diabetes mellitus; Diabetic neuropathy; inflammation; neuropathy; Oxidative stress; turmeric
• ISSN: 0022-3573; 2042-7158
• DOI: 10.1111/jphp.13075

Objectives Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti‐inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done. A number of book chapters and encyclopaedias were taken into consideration to find out the origin, botany and genetics. The databases were searched using different keywords like antioxidant, inflammation, turmeric, diabetic neuropathy. Key findings After getting data on pathogenesis of diabetic neuropathy, it has been found out that its role as antioxidant will reduce the level of oxidative stress which is the main reason for the occurrence of the present complication. Apart this, the anti‐inflammatory activity will further prevent the inflammation of neurons and antibacterial effect will inhibit the spread of infection. Combining all the factors together, the plant can be utilized in the treatment of diabetic neuropathy. Summary Curcuma caesia can be proved as a useful approach in the treatment of diabetic neuropathy.