Measurement of melatonin, indole‐dioxygenase, IL‐6, IL‐18, ferritin, CRP, and total homocysteine levels during herpes zoster

The risk of herpes zoster (HZ) increases with age and declining immune function. Increased oxidative stress and inflammatory conditions may cause a negative impact on the immune responses. The present study aimed to assess the levels of oxidative/inflammatory stress biomarkers in HZ patients compare...

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Bibliographic Details
Published in:Journal of medical virology 2020-08, Vol.92 (8), p.1253-1259
Main Authors: Khazan, Marjan, Nasiri, Soheila, Riahi, Seyed M., Robati, Reza M., Hedayati, Mehdi
Format: Article
Language:English
Subjects:
Biomarkers
Confidence intervals
Cytokines
Dioxygenase
Ferritin
Herpes zoster
Homocysteine
Immune response
Indoles
indole‐dioxygenase
Inflammation
Interleukins
Levels
Melatonin
Oxidative stress
Pain
Regression models
Statistical analysis
Virology
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Summary:The risk of herpes zoster (HZ) increases with age and declining immune function. Increased oxidative stress and inflammatory conditions may cause a negative impact on the immune responses. The present study aimed to assess the levels of oxidative/inflammatory stress biomarkers in HZ patients compared with the controls. This case‐control study included 43 HZ patients and 47 age‐matched controls. Melatonin (MLT), Indole‐dioxygenase (IDO), Interleukin‐18 (IL‐18), Interleukin‐6 (IL‐6), ferritin, C‐reactive protein (hsCRP), and total homocysteine (tHcy) levels were measured and compared in both groups. The significant high levels of IDO, IL‐18, IL‐6, ferritin, hsCRP, and tHcy, as well as low levels of MLT were found in HZ patients compared with the controls (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25484