Expanding the activity spectrum of antiviral agents

•Broad-spectrum antivirals target ≥3 viral diseases.•108 safe-in-man broad-spectrum antiviral agents were identified.•These agents could reinforce the arsenal of available antiviral therapeutics. Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we...

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Bibliographic Details
Published in:Drug discovery today 2019-05, Vol.24 (5), p.1224-1228
Main Authors: Ianevski, Aleksandr, Andersen, Petter I., Merits, Andres, Bjørås, Magnar, Kainov, Denis
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Drug Discovery
Drug Repositioning
Humans
Viruses - drug effects
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Summary:•Broad-spectrum antivirals target ≥3 viral diseases.•108 safe-in-man broad-spectrum antiviral agents were identified.•These agents could reinforce the arsenal of available antiviral therapeutics. Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2019.04.006