Advances in understanding the regulatory mechanism of cholesterol 7α-hydroxylase

[Display omitted] The conversion of cholesterol to bile acids (BAs) contributes to the elimination of total cholesterol from the body. In addition, manipulating BA homeostasis by modulating cholesterol 7α-hydroxylase (CYP7A1) may affect the metabolic processing of cholesterol, exerting therapeutic e...

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Bibliographic Details
Published in:Biochemical pharmacology 2019-06, Vol.164, p.152-164
Main Authors: Ge, Mao-xu, Shao, Rong-guang, He, Hong-wei
Format: Article
Language:English
Subjects:
Animals
Bile acid
Cholesterol - metabolism
Cholesterol 7-alpha-Hydroxylase - metabolism
CYP7A1
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
Gut microbiome
Homeostasis - physiology
Humans
Hypercholesterolemia
Hypercholesterolemia - drug therapy
Hypercholesterolemia - metabolism
microRNAs
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Summary:[Display omitted] The conversion of cholesterol to bile acids (BAs) contributes to the elimination of total cholesterol from the body. In addition, manipulating BA homeostasis by modulating cholesterol 7α-hydroxylase (CYP7A1) may affect the metabolic processing of cholesterol, exerting therapeutic effects on hypercholesterolemia and cardiovascular diseases. Multiple mechanisms (such as various nuclear receptors and regulatory factors) are involved in CYP7A1 modulation. Recently, microRNAs, protein degradation pathways, and the gut microbiota have been identified to participate in these sophisticated networks. In this review, research progress on the regulatory mechanism of CYP7A1 is summarized.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2019.04.008