Maternal breast milk feeding and length of treatment in infants with neonatal abstinence syndrome

Objective The objective of this study is to assess whether infants with neonatal abstinence syndrome (NAS), who receive maternal breast milk (BM), have shorter pharmacological treatment durations and lengths of stay compared with formula-fed infants. Study Design Retrospective data analysis from Opt...

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Bibliographic Details
Published in:Journal of perinatology 2019-06, Vol.39 (6), p.876-882
Main Authors: Favara, Michael T., Carola, David, Jensen, Erik, Cook, Alison, Genen, Linda, Dysart, Kevin, Greenspan, Jay S., Aghai, Zubair H.
Format: Article
Language:English
Subjects:
692/308/409
692/699/375/2764
692/700/1720
Analgesics, Opioid - adverse effects
Baby foods
Breast feeding
Breast Feeding - statistics & numerical data
Breast milk
Breastfeeding & lactation
Case-Control Studies
Comparative analysis
Data analysis
Databases, Factual
Drug therapy
Drug withdrawal
Feeding
Female
Health aspects
Humans
Infant formulas
Infant, Newborn
Infants
Length of Stay - statistics & numerical data
Male
Medicine
Medicine & Public Health
Milk, Human
Neonatal abstinence syndrome
Neonatal Abstinence Syndrome - drug therapy
Neonates
Newborn babies
Pediatric research
Pediatric Surgery
Pediatrics
Pharmacology
Pregnancy
Retrospective Studies
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Summary:Objective The objective of this study is to assess whether infants with neonatal abstinence syndrome (NAS), who receive maternal breast milk (BM), have shorter pharmacological treatment durations and lengths of stay compared with formula-fed infants. Study Design Retrospective data analysis from Optum Neonatal Database for infants born between 1 January 2010 and 21 November 2016, who received treatment for NAS. Clinical characteristics and outcomes were compared between infants who received any amount of BM and those exclusively formula-fed. Result Infants (1738) were analyzed. Median length of pharmacological treatment was significantly lower in infants who received any BM (14 days) compared with “no BM” group (17 days, p  = 0.04). Similarly, median length of hospitalization was significantly reduced in “any BM” group (19 days vs. 20 days), which remained significant after adjustment for confounders ( p  = 0.01). There was no difference in hospital re-admission rates. Conclusion Feeding any BM to infants with NAS was associated with both decreased lengths of pharmacological treatment and hospital stay compared with exclusively formula-fed infants.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-019-0374-1