Isopimarane-type diterpenoids from Croton laevigatus

A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antib...

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Bibliographic Details
Published in:Natural product research 2020-10, Vol.34 (20), p.1-2980
Main Authors: Li, Man-Yu, Han, Zheng-Zhi, Liu, Li-Fang, Wu, Xiao-Zhen, Huang, Wen-Jun, Wang, Kai, Yang, Fan, Yuan, Cheng-Shan
Format: Article
Language:English
Subjects:
Antibacterial activity
Bacteria
Diterpenes
Drug resistance
E coli
Klebsiella
Methicillin
NMR
Nuclear magnetic resonance
Staphylococcus infections
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Summary:A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities. Unfortunately, the compounds showed no antibacterial activity against Micrococcus luteus, Methicillin-resistant Staphylococcus aureus, Aeromonas hydrophila, Klebsiella pneumoniae ssp pneumoniae, Acinetobacter Baumanii, and Escherichia coli.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1596096