Antimicrobial substances from Amazonian Aniba ( Lauraceae ) species

Extracts and six isolated substances from ( ) Amazonian species , and were analysed to their antibacterial, antiparasitic and antiplasmodial activities. NMR and MS experiments led to the identification of three styrylpyrones (5,6-dihydrokawain [I], 4-methoxy-11,12-methylenedioxy-6- -styryl-pyran-2-o...

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Bibliographic Details
Published in:Natural product research 2021-03, Vol.35 (5), p.849-852
Main Authors: da Silva, Yasmin Cunha, Silva, Emily Marcele Soares, Fernandes, Nilma de Souza, Lopes, Nathália Lamenha, Orlandi, Patrícia Puccinelli, Nakamura, Celso Vataru, Costa, Emmanoel Vilaça, da Veiga Júnior, Valdir Florêncio
Format: Article
Language:English
Subjects:
Aniba
Anti-Bacterial Agents - pharmacology
Antimalarials - chemistry
Antimalarials - pharmacology
Antiparasitic agents
Antiprotozoal agents
Bacteria - drug effects
Dichloromethane
Drug resistance
Hexanes
Lauraceae
Lauraceae - chemistry
Microbial Sensitivity Tests
Minimum inhibitory concentration
NMR
Nuclear magnetic resonance
Oct-4 protein
Parasites
Phytochemicals - analysis
Phytochemicals - chemistry
Plant Extracts - chemistry
Plasmodium falciparum - drug effects
Pyridines
Pyrones - pharmacology
Trypanosoma cruzi - drug effects
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Summary:Extracts and six isolated substances from ( ) Amazonian species , and were analysed to their antibacterial, antiparasitic and antiplasmodial activities. NMR and MS experiments led to the identification of three styrylpyrones (5,6-dihydrokawain [I], 4-methoxy-11,12-methylenedioxy-6- -styryl-pyran-2-one [II] and -(6R,7S,8S,5'S)-4'-methoxy-8-(11,12-dimethoxyphenyl-7-[6-(4-methoxy-2-pyranyl)]-6-( )-styryl-1'-oxabicyclo[4,2,0]oct-4'-en-2'-one [III]), a pyridine alkaloid (anibine [IV]) and two kavalactones (tetrahydroyangonin [V] and dihydromethysticin [VI]). The best antibacterial result was observed at the hexane fraction of (MIC 7.8 μg/mL against the three bacteria). Equal MIC were observed by the extract and dichloromethane fraction of against and ; and 15.62 μg/mL against MRSA. Similarly, only extracts showed activities against and parasites. In assay, 5,6-dihydrokawain was considered an active antimalarial (14.03 μM), and substances II (132.94 μM) and III (41.84 μM) presented moderate activities.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1603225