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Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases
Background Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents....
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| Published in: | Alcoholism, clinical and experimental research clinical and experimental research, 2019-07, Vol.43 (7), p.1528-1532 |
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| cites | cdi_FETCH-LOGICAL-c3936-b417f25df27a988da45e7441e07e864ca99fd29dfcce4eba414f4489ce0dbe633 |
| container_end_page | 1532 |
| container_issue | 7 |
| container_start_page | 1528 |
| container_title | Alcoholism, clinical and experimental research |
| container_volume | 43 |
| creator | Porpiglia, Nadia M. Bortolotti, Federica Dorizzi, Romolo M. Micciolo, Rocco Tagliaro, Franco |
| description | Background
Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents. So far, however, the studies on the association of MCV with an increased risk of alcohol‐associated car accidents are extremely scarce, if not totally absent. To the best of our knowledge, the present work is the first specifically aimed at studying a plausible association between elevated MCV and crash accidents correlated with alcohol abuse.
Methods
A total of 6,244 drivers involved in traffic accidents underwent mandatory laboratory analyses including blood alcohol concentration (BAC) determination and MCV analysis. BAC and MCV determinations were performed by headspace gas chromatography and complete blood count, respectively.
Results
The chi‐square test evaluating the proportions of subjects with elevated MCVs (>95 fl) yielded a highly significant result (χ2 = 68.0; p 0.5 g/l). However, when considering only drivers showing BACs in the range of 0.51 to 1.5 g/l, the frequencies of elevated MCV values are fairly comparable (χ2 = 0.062, p = 0.80). In contrast, limiting the evaluation to BACs > 1.5 g/l, the frequency of elevated MCVs raised to 19.1% (χ2 = 58.9, p value |
| doi_str_mv | 10.1111/acer.14046 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2210335770</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2249728544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3936-b417f25df27a988da45e7441e07e864ca99fd29dfcce4eba414f4489ce0dbe633</originalsourceid><addsrcrecordid>eNp90U1u1DAYBmALUdFpYcMBkCU2CCnFTr78sQvRAJVaIQ2FbeSxP2tceeLBdqaaHUfoKTgYJ8FtWhYs8MaW9ej1z0vIS87OeBrvhER_xoFB9YQseFmwjOV1_ZQsGIcyqxhrjslJCNeMMWiq6hk5LljbVEXBF-RX7000Uli63As7iWjcSJ2mcYO0C8FJM299wHiDONKlxb2IqOglipH2zu-mICcrPP3u7LRFKkZFOyvdxtnfP29XaO_1lRdaG0k7KY3CMYb3tKMrjN6FHcpo9ki_xkkdaDqqygFonxJ7L8ImrQKG5-RICxvwxcN8Sr59XF71n7OLL5_O--4ik0VbVNkaeK3zUum8Fm3TKAEl1gAcWY1NBVK0rVZ5q7SUCLgWwEEDNK1EptaYfuSUvJlzd979mDDEYWuCRGvFiG4KQ55zVhRlXbNEX_9Dr93kx3S7pKCt86YESOrtrGR6avCoh503W-EPA2fDXXvDXXvDfXsJv3qInNZbVH_pY10J8BncGIuH_0QNXb9czaF_AGK2pow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2249728544</pqid></control><display><type>article</type><title>Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases</title><source>Wiley</source><creator>Porpiglia, Nadia M. ; Bortolotti, Federica ; Dorizzi, Romolo M. ; Micciolo, Rocco ; Tagliaro, Franco</creator><creatorcontrib>Porpiglia, Nadia M. ; Bortolotti, Federica ; Dorizzi, Romolo M. ; Micciolo, Rocco ; Tagliaro, Franco</creatorcontrib><description>Background
Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents. So far, however, the studies on the association of MCV with an increased risk of alcohol‐associated car accidents are extremely scarce, if not totally absent. To the best of our knowledge, the present work is the first specifically aimed at studying a plausible association between elevated MCV and crash accidents correlated with alcohol abuse.
Methods
A total of 6,244 drivers involved in traffic accidents underwent mandatory laboratory analyses including blood alcohol concentration (BAC) determination and MCV analysis. BAC and MCV determinations were performed by headspace gas chromatography and complete blood count, respectively.
Results
The chi‐square test evaluating the proportions of subjects with elevated MCVs (>95 fl) yielded a highly significant result (χ2 = 68.0; p < 0.001) in the blood samples where the BAC was above the legal limit (i.e., >0.5 g/l). However, when considering only drivers showing BACs in the range of 0.51 to 1.5 g/l, the frequencies of elevated MCV values are fairly comparable (χ2 = 0.062, p = 0.80). In contrast, limiting the evaluation to BACs > 1.5 g/l, the frequency of elevated MCVs raised to 19.1% (χ2 = 58.9, p value < 0.001 vs. the group with BAC within the legal limits).
Conclusions
The present observations show that MCV increases are typically associated with drivers involved in accidents only if driving under severe alcohol intoxication, leading to a preliminary conclusion that, in the context of the certification of the fitness to the driving license, MCV fails to reveal individuals at risk who tend to drive in a condition of low‐to‐moderate alcohol intoxication.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/acer.14046</identifier><identifier>PMID: 30986331</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Abuse ; Accidents ; Alcohol abuse ; Alcohol use ; Alcoholism ; Alcohols ; Alcohol‐Related Traffic Accident ; Bacterial artificial chromosomes ; Bioindicators ; Blood Alcohol Concentration ; Blood levels ; Chi-square test ; Dependence ; Driving ability ; Driving License ; Drug abuse ; Drug dependence ; Drunk Driving ; Drunkenness ; Erythrocytes ; Ethanol ; Evaluation ; Fitness ; Gas chromatography ; Headspace ; Intoxication ; Mean Corpuscular Volume ; Traffic ; Traffic accidents & safety</subject><ispartof>Alcoholism, clinical and experimental research, 2019-07, Vol.43 (7), p.1528-1532</ispartof><rights>2019 by the Research Society on Alcoholism</rights><rights>2019 by the Research Society on Alcoholism.</rights><rights>2019 Research Society on Alcoholism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3936-b417f25df27a988da45e7441e07e864ca99fd29dfcce4eba414f4489ce0dbe633</citedby><cites>FETCH-LOGICAL-c3936-b417f25df27a988da45e7441e07e864ca99fd29dfcce4eba414f4489ce0dbe633</cites><orcidid>0000-0002-9568-4585</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30986331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Porpiglia, Nadia M.</creatorcontrib><creatorcontrib>Bortolotti, Federica</creatorcontrib><creatorcontrib>Dorizzi, Romolo M.</creatorcontrib><creatorcontrib>Micciolo, Rocco</creatorcontrib><creatorcontrib>Tagliaro, Franco</creatorcontrib><title>Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background
Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents. So far, however, the studies on the association of MCV with an increased risk of alcohol‐associated car accidents are extremely scarce, if not totally absent. To the best of our knowledge, the present work is the first specifically aimed at studying a plausible association between elevated MCV and crash accidents correlated with alcohol abuse.
Methods
A total of 6,244 drivers involved in traffic accidents underwent mandatory laboratory analyses including blood alcohol concentration (BAC) determination and MCV analysis. BAC and MCV determinations were performed by headspace gas chromatography and complete blood count, respectively.
Results
The chi‐square test evaluating the proportions of subjects with elevated MCVs (>95 fl) yielded a highly significant result (χ2 = 68.0; p < 0.001) in the blood samples where the BAC was above the legal limit (i.e., >0.5 g/l). However, when considering only drivers showing BACs in the range of 0.51 to 1.5 g/l, the frequencies of elevated MCV values are fairly comparable (χ2 = 0.062, p = 0.80). In contrast, limiting the evaluation to BACs > 1.5 g/l, the frequency of elevated MCVs raised to 19.1% (χ2 = 58.9, p value < 0.001 vs. the group with BAC within the legal limits).
Conclusions
The present observations show that MCV increases are typically associated with drivers involved in accidents only if driving under severe alcohol intoxication, leading to a preliminary conclusion that, in the context of the certification of the fitness to the driving license, MCV fails to reveal individuals at risk who tend to drive in a condition of low‐to‐moderate alcohol intoxication.</description><subject>Abuse</subject><subject>Accidents</subject><subject>Alcohol abuse</subject><subject>Alcohol use</subject><subject>Alcoholism</subject><subject>Alcohols</subject><subject>Alcohol‐Related Traffic Accident</subject><subject>Bacterial artificial chromosomes</subject><subject>Bioindicators</subject><subject>Blood Alcohol Concentration</subject><subject>Blood levels</subject><subject>Chi-square test</subject><subject>Dependence</subject><subject>Driving ability</subject><subject>Driving License</subject><subject>Drug abuse</subject><subject>Drug dependence</subject><subject>Drunk Driving</subject><subject>Drunkenness</subject><subject>Erythrocytes</subject><subject>Ethanol</subject><subject>Evaluation</subject><subject>Fitness</subject><subject>Gas chromatography</subject><subject>Headspace</subject><subject>Intoxication</subject><subject>Mean Corpuscular Volume</subject><subject>Traffic</subject><subject>Traffic accidents & safety</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp90U1u1DAYBmALUdFpYcMBkCU2CCnFTr78sQvRAJVaIQ2FbeSxP2tceeLBdqaaHUfoKTgYJ8FtWhYs8MaW9ej1z0vIS87OeBrvhER_xoFB9YQseFmwjOV1_ZQsGIcyqxhrjslJCNeMMWiq6hk5LljbVEXBF-RX7000Uli63As7iWjcSJ2mcYO0C8FJM299wHiDONKlxb2IqOglipH2zu-mICcrPP3u7LRFKkZFOyvdxtnfP29XaO_1lRdaG0k7KY3CMYb3tKMrjN6FHcpo9ki_xkkdaDqqygFonxJ7L8ImrQKG5-RICxvwxcN8Sr59XF71n7OLL5_O--4ik0VbVNkaeK3zUum8Fm3TKAEl1gAcWY1NBVK0rVZ5q7SUCLgWwEEDNK1EptaYfuSUvJlzd979mDDEYWuCRGvFiG4KQ55zVhRlXbNEX_9Dr93kx3S7pKCt86YESOrtrGR6avCoh503W-EPA2fDXXvDXXvDfXsJv3qInNZbVH_pY10J8BncGIuH_0QNXb9czaF_AGK2pow</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Porpiglia, Nadia M.</creator><creator>Bortolotti, Federica</creator><creator>Dorizzi, Romolo M.</creator><creator>Micciolo, Rocco</creator><creator>Tagliaro, Franco</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9568-4585</orcidid></search><sort><creationdate>201907</creationdate><title>Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases</title><author>Porpiglia, Nadia M. ; Bortolotti, Federica ; Dorizzi, Romolo M. ; Micciolo, Rocco ; Tagliaro, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3936-b417f25df27a988da45e7441e07e864ca99fd29dfcce4eba414f4489ce0dbe633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abuse</topic><topic>Accidents</topic><topic>Alcohol abuse</topic><topic>Alcohol use</topic><topic>Alcoholism</topic><topic>Alcohols</topic><topic>Alcohol‐Related Traffic Accident</topic><topic>Bacterial artificial chromosomes</topic><topic>Bioindicators</topic><topic>Blood Alcohol Concentration</topic><topic>Blood levels</topic><topic>Chi-square test</topic><topic>Dependence</topic><topic>Driving ability</topic><topic>Driving License</topic><topic>Drug abuse</topic><topic>Drug dependence</topic><topic>Drunk Driving</topic><topic>Drunkenness</topic><topic>Erythrocytes</topic><topic>Ethanol</topic><topic>Evaluation</topic><topic>Fitness</topic><topic>Gas chromatography</topic><topic>Headspace</topic><topic>Intoxication</topic><topic>Mean Corpuscular Volume</topic><topic>Traffic</topic><topic>Traffic accidents & safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porpiglia, Nadia M.</creatorcontrib><creatorcontrib>Bortolotti, Federica</creatorcontrib><creatorcontrib>Dorizzi, Romolo M.</creatorcontrib><creatorcontrib>Micciolo, Rocco</creatorcontrib><creatorcontrib>Tagliaro, Franco</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porpiglia, Nadia M.</au><au>Bortolotti, Federica</au><au>Dorizzi, Romolo M.</au><au>Micciolo, Rocco</au><au>Tagliaro, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2019-07</date><risdate>2019</risdate><volume>43</volume><issue>7</issue><spage>1528</spage><epage>1532</epage><pages>1528-1532</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><abstract>Background
Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents. So far, however, the studies on the association of MCV with an increased risk of alcohol‐associated car accidents are extremely scarce, if not totally absent. To the best of our knowledge, the present work is the first specifically aimed at studying a plausible association between elevated MCV and crash accidents correlated with alcohol abuse.
Methods
A total of 6,244 drivers involved in traffic accidents underwent mandatory laboratory analyses including blood alcohol concentration (BAC) determination and MCV analysis. BAC and MCV determinations were performed by headspace gas chromatography and complete blood count, respectively.
Results
The chi‐square test evaluating the proportions of subjects with elevated MCVs (>95 fl) yielded a highly significant result (χ2 = 68.0; p < 0.001) in the blood samples where the BAC was above the legal limit (i.e., >0.5 g/l). However, when considering only drivers showing BACs in the range of 0.51 to 1.5 g/l, the frequencies of elevated MCV values are fairly comparable (χ2 = 0.062, p = 0.80). In contrast, limiting the evaluation to BACs > 1.5 g/l, the frequency of elevated MCVs raised to 19.1% (χ2 = 58.9, p value < 0.001 vs. the group with BAC within the legal limits).
Conclusions
The present observations show that MCV increases are typically associated with drivers involved in accidents only if driving under severe alcohol intoxication, leading to a preliminary conclusion that, in the context of the certification of the fitness to the driving license, MCV fails to reveal individuals at risk who tend to drive in a condition of low‐to‐moderate alcohol intoxication.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30986331</pmid><doi>10.1111/acer.14046</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9568-4585</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0145-6008 |
| ispartof | Alcoholism, clinical and experimental research, 2019-07, Vol.43 (7), p.1528-1532 |
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| language | eng |
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| source | Wiley |
| subjects | Abuse Accidents Alcohol abuse Alcohol use Alcoholism Alcohols Alcohol‐Related Traffic Accident Bacterial artificial chromosomes Bioindicators Blood Alcohol Concentration Blood levels Chi-square test Dependence Driving ability Driving License Drug abuse Drug dependence Drunk Driving Drunkenness Erythrocytes Ethanol Evaluation Fitness Gas chromatography Headspace Intoxication Mean Corpuscular Volume Traffic Traffic accidents & safety |
| title | Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol‐Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases |
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