Influence of male human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection on the reproductive outcomes in serodiscordant couples: a case–control study

Background Nowadays, serodiscordant couples (SDCs) with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)‐infected men have the chance to conceive safely, giving birth with a minimum risk of cross‐infection. Objective To assess the impact of male HIV and HCV infection on the assisted rep...

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Bibliographic Details
Published in:Andrology (Oxford) 2019-11, Vol.7 (6), p.852-858
Main Authors: Cito, G., Coccia, M. E., Fucci, R., Picone, R., Cocci, A., Russo, G. I., Rizzello, F., Trotta, M., Badolato, L., Basile, V., Criscuoli, L., Serni, S., Carini, M., Natali, A.
Format: Article
Language:English
Subjects:
Birth rate
HCV
Hepatitis
Hepatitis C
HIV
Human immunodeficiency virus
Infections
intracytoplasmic sperm injection
Reproductive health
Sperm
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Summary:Background Nowadays, serodiscordant couples (SDCs) with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)‐infected men have the chance to conceive safely, giving birth with a minimum risk of cross‐infection. Objective To assess the impact of male HIV and HCV infection on the assisted reproductive technologies (ART) outcomes in SDCs, with HIV or HCV seropositive men and negative partners. Materials and methods Of 153 couples: 24 in Group 1 (HIV‐seropositive men), 60 in Group 2 (HCV‐seropositive men) and 69 in Group 3 (controls). Sperm‐washing procedure was performed using a three‐step system. Fresh ICSI cycles were carried out in HIV SDCs, HCV SDCs and controls. Seminal parameters, fertilization rate (FR), cleavage rate (CR), pregnancy rate per cycle (PR/C), miscarriage rate, implantation rate (IR) and live birth rate were evaluated. Results All the seropositive men have undetectable viral loads at the time of insemination, and both partners were free from co‐morbid infections. The median number of embryos transferred was 2.0 (IQR 1.0–3.0), with no differences among groups. FR was significantly reduced in HIV and HCV SDCs compared to the controls (66%, 61% and 75%, respectively; p 
ISSN:2047-2919
2047-2927
DOI:10.1111/andr.12623