Endogenous and exogenous effects of PGF2α during luteolysis in mares

An inhibitor of PGF2α biosynthesis (flunixin meglumine, FM) was used to study the role of endogenous PGF2α on the luteolytic effect of exogenous PGF2α in mares. A 2-h infusion of PGF2α at a constant rate (total dose, 0.1 mg) on Day 10 (ovulation = Day 0) was used to mimic the maximal concentrations...

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Bibliographic Details
Published in:Theriogenology 2019-07, Vol.132, p.45-52
Main Authors: Ginther, O.J., Domingues, R.R., Kennedy, V.C., Dangudubiyyam, S.V.
Format: Article
Language:English
Subjects:
Luteolysis
Mares
Persistent CL
PGF2α auto-amplification
PGF2α inhibitor
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Summary:An inhibitor of PGF2α biosynthesis (flunixin meglumine, FM) was used to study the role of endogenous PGF2α on the luteolytic effect of exogenous PGF2α in mares. A 2-h infusion of PGF2α at a constant rate (total dose, 0.1 mg) on Day 10 (ovulation = Day 0) was used to mimic the maximal concentrations of a spontaneous pulse of a PGF2α metabolite (PGFM). Treatment with FM (1.7 mg/kg) was done 1 h before and 5 h after the start of PGF2α infusion. In hourly blood samples beginning 1 h before the start of PGF2α infusion, progesterone decreased (P 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2019.04.004