Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family—IL-18, IL-33, IL-36, IL-37, and IL-38—in i...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2019-04, Vol.50 (4), p.778-795
Main Authors: Mantovani, Alberto, Dinarello, Charles A., Molgora, Martina, Garlanda, Cecilia
Format: Article
Language:English
Subjects:
Adaptive immunity
Adaptive Immunity - immunology
Animals
Autoimmune diseases
Autoimmunity
Cancer
Cardiovascular Diseases - immunology
Cloning
Cytokines
Cytokines - genetics
Cytokines - immunology
Cytokines - physiology
Gastrointestinal Diseases - immunology
Hematopoiesis - immunology
Homeostasis
Humans
Immune response
Immunity
Immunity, Innate - immunology
Inflammation
Inflammation - immunology
Interleukin 1
Interleukin 18
Interleukin-1 - immunology
Interleukin-1 - physiology
Kinases
Ligands
Lymphocytes - immunology
Mice
Mice, Knockout
Multigene Family
Neoplasms - immunology
Neurodegenerative Diseases - immunology
Proteins
Receptors, Cytokine - genetics
Receptors, Cytokine - immunology
Regulation
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Summary:Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by the growing understanding of its context-dependent roles and advances in the clinic. Recent studies have identified important roles for members of the IL-1 family—IL-18, IL-33, IL-36, IL-37, and IL-38—in inflammation and immunity. Here, we review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and their diversity and plasticity. We discuss the varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer. The trans-disease therapeutic activity of anti-IL-1 strategies argues for immunity and inflammation as a metanarrative of modern medicine. Mantovani et al. review the complex functions of IL-1 family members in the orchestration of innate and adaptive immune responses and discuss how our growing understanding of the context-dependent roles of these cytokines are informing advances in the clinic.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2019.03.012