In-vitro blood and vascular compatibility of sirolimus-eluting organic/inorganic hybrid stent coatings

[Display omitted] •Chitosan-silica hybrid coating for metal stents was fabricated by sol-gel method.•The coating had robust mechanical stability and good adhesive strength.•The coated Co-Cr stent showed improved wettability and corrosion resistance.•The hybrid coating enabled efficient loading and s...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-07, Vol.179, p.405-413
Main Authors: Jang, Tae-Sik, Cheon, Kwang-Hee, Ahn, Ji-Ho, Song, Eun-Ho, Kim, Hyoun-Ee, Jung, Hyun-Do
Format: Article
Language:English
Subjects:
Chitosan
Coating
Silica xerogel
Sirolimus
Stent
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Summary:[Display omitted] •Chitosan-silica hybrid coating for metal stents was fabricated by sol-gel method.•The coating had robust mechanical stability and good adhesive strength.•The coated Co-Cr stent showed improved wettability and corrosion resistance.•The hybrid coating enabled efficient loading and sustained release of sirolimus.•The hybrid coat had excellent cytocompatibility and hemocompatibilty. The surface characteristics of coronary stents play a pivotal role in inhibiting in-stent restenosis and late-stent thrombosis. In this study, a sol-gel-derived silica xerogel-chitosan hybrid coating was applied to Co-Cr stent and was reported, for the first time, as a biocompatible drug delivery tool in vascular stent application. A dense and uniform chitosan-silica xerogel hybrid coating (
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2019.04.018