Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy

•Ultrasound stimulation can suppress the bursts and slow frequency dynamics of TLE.•Ultrasound stimulation can effectively inhibit seizures in TLE.•This inhibition effect is independent of ultrasound type. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have de...

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Bibliographic Details
Published in:Epilepsy research 2019-08, Vol.154, p.1-7
Main Authors: Li, Xin, Yang, Huifang, Yan, Jiaqing, Wang, Xingran, Yuan, Yi, Li, Xiaoli
Format: Article
Language:English
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Summary:•Ultrasound stimulation can suppress the bursts and slow frequency dynamics of TLE.•Ultrasound stimulation can effectively inhibit seizures in TLE.•This inhibition effect is independent of ultrasound type. Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous recurrent seizures and improve behavioral outcomes for rodents with TLE. However, the exact underlying mechanism for inhibition of TLE via ultrasound stimulation remains unknown. In this study, low-intensity pulsed ultrasound stimulation (LIPUS) and low-intensity continuous ultrasound stimulation (LICUS) and concurrent local field potentials (LFPs) in the CA3 field of the hippocampus were recorded in the kainite-induced mouse model of TLE. The power spectrum and the phase-amplitude coupling in the LFPs were quantitatively analyzed. We found three significant changes in LFPs after ultrasound stimulation: (i) the intensity of the power spectrum in the low frequency (
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2019.04.002