Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 express...

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Published in:Biotechnology advances 2020-01, Vol.38, p.107385-107385, Article 107385
Main Authors: Khan, Haroon, Reale, Marcella, Ullah, Hammad, Sureda, Antoni, Tejada, Silvia, Wang, Ying, Zhang, Zhang-Jin, Xiao, Jianbo
Format: Article
Language:English
Subjects:
Anticancer
Anticancer properties
Cell Line, Tumor
Chemoresistance
Clinical perspectives
Gene expression
Humans
Neoplasms
p53 signaling pathways
Polyphenols
Signal Transduction
Signaling
Tumor Suppressor Protein p53
Tumors
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cited_by cdi_FETCH-LOGICAL-c523t-976680ec17a4c97592cca5e493a7eab78417f5452bda2ff63f2e4d63b295da8a3
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container_end_page 107385
container_issue
container_start_page 107385
container_title Biotechnology advances
container_volume 38
creator Khan, Haroon
Reale, Marcella
Ullah, Hammad
Sureda, Antoni
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Wang, Ying
Zhang, Zhang-Jin
Xiao, Jianbo
description The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.
doi_str_mv 10.1016/j.biotechadv.2019.04.007
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source ScienceDirect Journals
subjects Anticancer
Anticancer properties
Cell Line, Tumor
Chemoresistance
Clinical perspectives
Gene expression
Humans
Neoplasms
p53 signaling pathways
Polyphenols
Signal Transduction
Signaling
Tumor Suppressor Protein p53
Tumors
title Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions
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