Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome

High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndr...

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Bibliographic Details
Published in:Clinica chimica acta 2019-07, Vol.494, p.151-156
Main Author: Jeenduang, Nutjaree
Format: Article
Language:English
Subjects:
Menopause
Metabolic parameters
Metabolic syndrome
PCSK9
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Summary:High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndrome (MetS). Anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations were measured in 436 Thai subjects (152 men, 143 premenopausal, and 141 postmenopausal women). PCSK9 concentrations were significantly higher in women than in men (p = .002) and increased in subjects with an increasing number of MetS components (p for trend = .011). PCSK9 concentrations were significantly higher in postmenopausal women than in premenopausal women (p 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2019.04.067