Persistent Circulation of Vaccine Serotypes and Serotype Replacement After 5 Years of Infant Immunization With 13-Valent Pneumococcal Conjugate Vaccine in the United Kingdom

Abstract Background Following programmatic introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), there is residual carriage and disease due to PCV13-covered serotypes. Methods PCV13-immunized children aged 13–48 months, N = 988, were enrolled between February 2014 and August 2015 (“l...

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Bibliographic Details
Published in:The Journal of infectious diseases 2020-03, Vol.221 (8), p.1361-1370
Main Authors: Kandasamy, Rama, Voysey, Merryn, Collins, Sarah, Berbers, Guy, Robinson, Hannah, Noel, Irene, Hughes, Harri, Ndimah, Susan, Gould, Katherine, Fry, Norman, Sheppard, Carmen, Ladhani, Shamez, Snape, Matthew D, Hinds, Jason, Pollard, Andrew J
Format: Article
Language:English
Subjects:
Babies
Bacterial infections
Carrier State - immunology
Carrier State - microbiology
Child, Preschool
Children
Cross-Sectional Studies
Female
Heptavalent Pneumococcal Conjugate Vaccine - immunology
Humans
Immunization
Immunization - methods
Incidence
Infant
Male
Nasopharynx - immunology
Nasopharynx - microbiology
Pediatrics
Pneumococcal Infections - immunology
Pneumococcal Vaccines - immunology
Respiratory diseases
Serogroup
Serotypes
Streptococcus pneumoniae - immunology
United Kingdom
Vaccination - methods
Vaccines
Vaccines, Conjugate - immunology
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Summary:Abstract Background Following programmatic introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), there is residual carriage and disease due to PCV13-covered serotypes. Methods PCV13-immunized children aged 13–48 months, N = 988, were enrolled between February 2014 and August 2015 (“late PCV13”), and had nasopharyngeal pneumococcal carriage compared with 7-valent pneumococcal conjugate vaccine (PCV7) immunized children, N = 567, enrolled between November 2010 and September 2011 (“early PCV13”). Nasopharyngeal pneumococci were molecular-serotyped by microarray. Invasive pneumococcal disease (IPD) cases were identified through enhanced national surveillance. Results Compared with PCV7-immunized children, carriage among PCV13-immunized children was significantly lower for serotypes 19A (odds ratio [OR], 0.08 [95% confidence interval {CI}, .02–.25]), 6C (OR, 0.11 [95% CI, .03–.32]), and 7F (8 vs 0 cases). IPD incidence in children
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiz178