Perineural Invasion in Cutaneous Squamous Cell Carcinoma

• Published in: Actas dermo-sifiliográficas (English ed.) 2019-07, Vol.110 (6), p.426-433
• Main Authors: Pérez García, M P, Mateu Puchades, A, Sanmartín Jiménez, O
• Format: Article
• Language: eng ; spa
• Subjects: Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Facial Neoplasms - diagnostic imaging; Facial Neoplasms - pathology; Facial Neoplasms - surgery; Facial Nerve - pathology; Humans; Incidental Findings; Magnetic Resonance Imaging; Mohs Surgery; Neoplasm Invasiveness - diagnostic imaging; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Peripheral Nerves - diagnostic imaging; Peripheral Nerves - pathology; Prognosis; Risk Factors; Skin Neoplasms - diagnostic imaging; Skin Neoplasms - pathology; Skin Neoplasms - surgery; Trigeminal Nerve - pathology
• ISSN: 2173-5778; 1578-2190
• DOI: 10.1016/j.ad.2018.10.006

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. In the presence of symptoms or radiographic evidence of perineural spread, the diagnosis is clinical perineural invasion, which is associated with an increased risk of local recurrence and mortality.