Effect of waterpipe tobacco smoke exposure during lactation on learning and memory of offspring rats: Role of oxidative stress

The prevalence of waterpipe tobacco smoking is increasing among breastfeeding women. Herein, the effect of maternal waterpipe tobacco smoke (WTS) exposure during lactation on learning and memory of adult offspring rats was examined. Lactating rats received either fresh air or mainstream WTS (1 h twi...

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Bibliographic Details
Published in:Life sciences (1973) 2019-06, Vol.227, p.58-63
Main Authors: Al-Sawalha, Nour A., Alzoubi, Karem H., Khabour, Omar F., Alyacoub, Weam, Almahmood, Yehya
Format: Article
Language:English
Subjects:
Biomarkers
Brain
Brain-derived neurotrophic factor
Breast feeding
Breastfeeding & lactation
Catalase
Cigarette smoking
Drug addiction
Exposure
Glutathione
Glutathione peroxidase
Hippocampus
Lactation
Learning
Learning and memory
Levels
Long term memory
Maze learning
Offspring
Oxidation
Oxidative stress
Peroxidase
Smoke
Smoking
Superoxide dismutase
Thiobarbituric acid
Tobacco
Tobacco smoke
Tobacco smoking
Water pipes
Waterpipe tobacco smoke
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Summary:The prevalence of waterpipe tobacco smoking is increasing among breastfeeding women. Herein, the effect of maternal waterpipe tobacco smoke (WTS) exposure during lactation on learning and memory of adult offspring rats was examined. Lactating rats received either fresh air or mainstream WTS (1 h twice daily) from day 4 to day 21. Learning and memory was examined by the radial arm water maze and the levels of brain derived neurotrophic factor (BDNF) and oxidative stress biomarkers superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase and thiobarbituric acid reactive substances (TBARS) were assessed in the hippocampus of adult male offspring rats. Maternal exposure to WTS during lactation impaired the long-term memory and reduced levels of BDNF (P 
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2019.04.049