Pentosidine in chronic hemodialysis patients: relation with arteriovenous fistula morphology and function

Purpose It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date,...

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Bibliographic Details
Published in:International urology and nephrology 2019-06, Vol.51 (6), p.1035-1042
Main Authors: Ticala, Maria, Tirinescu, Dacian Călin, Rusu, Crina Claudia, Moldovan, Diana, Potra, Alina Ramona, Coman, Anca Laura, Bondor, Cosmina Ioana, Budisan, Livia, Kacsó, Ina Maria
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Aged
Arginine - analogs & derivatives
Arginine - blood
Arteriovenous Shunt, Surgical
Atherogenesis
Blood flow
Calcification (ectopic)
Calcium
Cholesterol
Cross-Sectional Studies
Female
Fistula
Fistulae
Glycosylation
Hemodialysis
Humans
Hyperplasia
Lysine - analogs & derivatives
Lysine - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Morphology
Nephrology
Nephrology - Original Paper
Parathyroid
Parathyroid hormone
Pentosidine
Regional Blood Flow
Renal Dialysis
Stenosis
Thrombosis
Triglycerides
Ultrasound
Urea
Urology
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Summary:Purpose It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date, with only one clinical study addressing the issue of thrombosis of vascular access in relation to AGEs in dialysis patients. We aimed to evaluate the relationship between serum pentosidine and AVF morphology and function. Methods Eighty-eighth hemodialysis patients with patent native AVF were included. Ultrasound examination of AVF evaluated blood flow in the brachial artery, resistivity index (RI), the diameter of the vessels and the presence of stenosis. AVF and cardiovascular history were recorded, routine clinical and laboratory evaluation was performed and serum pentosidine was assessed. Results Forty-eight patients (54.54%) had AVF stenosis. Pentosidine correlated in univariate analysis with cholesterol ( r  = 0.270, p  = 0.01), triglycerides ( r  = 0.309, p  = 0.003), calcium ( r  = 0.040, p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-019-02151-z