Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na+ Transport in Frog Skin

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na + transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlo...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2019-05, Vol.484 (1), p.63-65
Main Authors: Krutetskaya, Z. I., Melnitskaya, A. V., Antonov, V. G., Nozdrachev, A. D.
Format: Article
Language:English
Subjects:
Amphibian Proteins - antagonists & inhibitors
Amphibian Proteins - metabolism
Amphibians
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Chlorpromazine
Chlorpromazine - pharmacology
Epithelium
Frogs
Haloperidol
Haloperidol - pharmacology
Immunomodulation
Ion Transport - drug effects
Life Sciences
Molecular Biology
Oligopeptides - pharmacology
Rana temporaria
Receptors, sigma - antagonists & inhibitors
Receptors, sigma - metabolism
Sigma-1 Receptor
Skin
Skin - metabolism
Sodium
Sodium - metabolism
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Summary:Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na + transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na + transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na + transport in frog skin epithelium by glutoxim.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672919010186