Experience of Antiseptic Application for Processing of Rat Lung Biological Matrices

To select the optimum method for disinfecting scaffolds before recellularization, the effects of octenisept and chlorhexidine at different concentrations on lung biological matrices before and after decellularization were studied by using morphological methods (studies of biomechanical strength of e...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2019-05, Vol.484 (1), p.48-51
Main Authors: Kuevda, E. V., Gubareva, E. A., Basov, A. A., Krasheninnikov, S. V., Grigoriev, T. E., Gumenyuk, I. S., Dzhimak, S. S., Kachanova, O. A., Chvalun, S. N.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents, Local - chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Chemiluminescence
Chlorhexidine
Chlorhexidine - chemistry
Disinfection
Disinfection - methods
Extracellular matrix
Extracellular Matrix - chemistry
Life Sciences
Lung - chemistry
Lungs
Molecular Biology
Rats
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Summary:To select the optimum method for disinfecting scaffolds before recellularization, the effects of octenisept and chlorhexidine at different concentrations on lung biological matrices before and after decellularization were studied by using morphological methods (studies of biomechanical strength of extracellular matrix fibers) and by analyzing chemiluminescence in rats. Chlorhexidine diluted 1 : 10 had the least damage on the matrix properties and to the greatest extent contributed to disinfection of scaffolds for their further storage and experimental studies.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672919010149