Janus Gold Nanostars–Mesoporous Silica Nanoparticles for NIR‐Light‐Triggered Drug Delivery

Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous sil...

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Bibliographic Details
Published in:Chemistry : a European journal 2019-06, Vol.25 (36), p.8471-8478
Main Authors: Hernández Montoto, Andy, Llopis‐Lorente, Antoni, Gorbe, Mónica, M. Terrés, José, Cao‐Milán, Roberto, Díaz de Greñu, Borja, Alfonso, María, Ibañez, Javier, Marcos, María D., Orzáez, Mar, Villalonga, Reynaldo, Martínez‐Máñez, Ramón, Sancenón, Félix
Format: Article
Language:English
Subjects:
Benzimidazoles
Chemistry
Cyclodextrin
Cyclodextrins
Cytotoxicity
Doxorubicin
Drug delivery
Drug delivery systems
Gold
Hyperthermia
I.R. radiation
Infrared radiation
Irradiation
light-responsive nanodevices
mesoporous silica
Nanoparticles
Nanotechnology devices
NIR light
Organic chemistry
Photochemicals
Silica
Silicon dioxide
Succinic acid
Viability
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Summary:Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton‐responsive benzimidazole‐β‐cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR‐light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR‐light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non‐cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability. NIR‐light irradiation of a Janus gold nanostar–mesoporous silica nanoparticle nanodevice induced succinic acid generation and doxorubicin release due to the dethreading of a supramolecular nanovalve.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201900750