Prevalence of Helicobacter pylori infection in Latin America and the Caribbean populations: A systematic review and meta-analysis

•The burden of incidence and mortality of gastric cancer in Latin. America and the Caribbean (LAC) countries remain high.•In this meta-analysis, we observed that the prevalence of Helicobacter pylori infection was 57.57% in LAC.•This infection was found in early ages (childhood) and during the whole...

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Bibliographic Details
Published in:Cancer epidemiology 2019-06, Vol.60, p.141-148
Main Authors: Curado, Maria Paula, de Oliveira, Max Moura, de Araújo Fagundes, Marcela
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Age
Age groups
Antigens
Cancer
Caribbean Region
Child
Child, Preschool
Children
Confidence intervals
Data collection
Epidemiology
Female
Gastric cancer
Gender
Helicobacter Infections - epidemiology
Helicobacter pylori
Histology
Humans
Incidence
Infant
Infant, Newborn
Infections
Latin America
Male
Meta-analysis
Population
Population studies
Prevalence
Reviews
Socioeconomic factors
Systematic review
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Summary:•The burden of incidence and mortality of gastric cancer in Latin. America and the Caribbean (LAC) countries remain high.•In this meta-analysis, we observed that the prevalence of Helicobacter pylori infection was 57.57% in LAC.•This infection was found in early ages (childhood) and during the whole studied period evaluated. To describe the prevalence of Helicobacter pylori (H. pylori) infection in Latin Americaand the Caribbean (LAC), through systematic review and meta-analysis by age groups and gender. Systematic review and meta-analysis of the population-based observational epidemiological studies carried out in LAC, focused on the prevalence of H. pylori and published until March, 2018. The databases utilized in the search were MEDLINE, SCIELO andPUBMED. The prevalence described in the meta-analysis and 95% confidence intervals were estimated by the random effects model, and weighted by the size of the study. The 22 selected studies were carried out in 14 countries of LAC, and included 24,178 individuals. The studies were conducted between 1987 and 2012, and all were representative of at least one city. The prevalence of H. pylori infection was 57.57% (CI95%:50.43;64.72) for all ages; in children and adolescents the prevalence was 48.36% (CI95%:38.03;58.70) and in adults 69.26%(CI95%:64.54;76.99). No differences were observed regarding sex. Prevalence of H. pylori infection in LAC is high for all age groups. These data reinforce the necessity of actions towards the prevention and treatment of H. pylori infection for all age groups. Treating H pylori infection in young ages probably will reduce gastric cancer incidence in the future.
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2019.04.003